Recruitment

Recruitment Status
Unknown status
Estimated Enrollment
300

Summary

Conditions
  • Autoimmune Diseases
  • Common Variable Immune Deficiencies
  • Hypogammaglobulinemia
  • Inflammatory Diseases
  • Primary Immune Deficiencies
Type
Observational
Design
  • Observational Model: Case-Control
  • Time Perspective: Prospective

Participation Requirements

Max Age
125
Gender
Both

Description

Primary immunodeficiency diseases (PID) represent a class of disorders in which there is an instrinsic defect in the human immune system. The PID could be caused by defects or perturbations in either the innate or adaptive immune cells, such as B cell defects which result in lack of antibodies. Rese...

Primary immunodeficiency diseases (PID) represent a class of disorders in which there is an instrinsic defect in the human immune system. The PID could be caused by defects or perturbations in either the innate or adaptive immune cells, such as B cell defects which result in lack of antibodies. Research in this topic remains a difficult feat due factors such as genetic heterogeneity and the gene-environment interface. Limitations of standard of care testing leads to many patients with immunological problems to be undiagnosed. In addition to the variety of primary immune deficiencies, there are large number of immune system disorders due to various perturbations in the immunological components that cause diseases with much greater prevalence such as autoimmune diseases, lymphoproliferative diseases, chronic inflammation and certain cancers. The causes of these immune disorders are typically more complex than PID but there are also many overlaps in immune hyper-activation and deficiency.

Locations

Fairfax, Virginia, 22030
Fairfax, Virginia, 22030

Tracking Information

NCT #
NCT01981785
Collaborators
Not Provided
Investigators
  • Principal Investigator: Oral Alpan, MD O & O Alpan LLC
  • Oral Alpan, MD O & O Alpan LLC