Recruitment

Recruitment Status
Unknown status
Estimated Enrollment
60

Inclusion Criterias

Planned use of spinal anaesthesia
Scheduled for elective total knee arthroplasty
Signed written informed consent
...
Planned use of spinal anaesthesia
Scheduled for elective total knee arthroplasty
Signed written informed consent
Cognitive sound to use assessment tools
Diagnosis of primary osteoarthritis

Exclusion Criterias

Patient outside range of 30 to 80 yrs old
Cognitive impairment/ inability to use the outcome assessment tools
Patients refusing to give consents
...
Patient outside range of 30 to 80 yrs old
Cognitive impairment/ inability to use the outcome assessment tools
Patients refusing to give consents
Non-chinese population
drug abuser
Moderate or severe renal impairment (serum creatinine > 160 micromol/l)
Scheduled for revision total knee replacement
severe cardiovascular disease (unstable angina, second or third degree heart block)
Pre-operative history of neurological abnormality in the ipsilateral leg e.g. history of stroke, neurogenic pain or previous nerve injury.
Contraindications to regional anesthesia
Allergy or contraindication to drugs used in this study: morphine, Non-steroidal anti-inflammatory drugs (NSAID) such as ketorolac , diclofenac, dihydrocodeine, local anaesthetics (lignocaine, ropivacaine, bupivacaine), epinephrine
pre-existing neurologic disease including psychiatric disorder

Summary

Conditions
Osteoarthritis
Type
Interventional
Phase
Phase 4
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Single (Outcomes Assessor)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 30 years and 80 years
Gender
Both males and females

Description

A total of 80 patients who will undergo total knee arthroplasty will be randomized into two groups: Treatment groups Treatment details Femoral Group (40 patients) Continuous femoral nerve block (bolus: 0.5% Ropivacaine 10-15 ml ; infusion of 0.15 % Ropivacaine 4-6ml/h) Adductor Group (40 patients) A...

A total of 80 patients who will undergo total knee arthroplasty will be randomized into two groups: Treatment groups Treatment details Femoral Group (40 patients) Continuous femoral nerve block (bolus: 0.5% Ropivacaine 10-15 ml ; infusion of 0.15 % Ropivacaine 4-6ml/h) Adductor Group (40 patients) Adductor canal block with steroid adjuvant (bolus: 0.5% Ropivacaine 10-15ml; Dexamethasone 4mg) (Total 80 patients will be recruited) All patients will receive single shot tibial nerve block with local anaesthetics (0.5% Ropivacaine 5-8ml) before surgery for analgesia of posterior knee. All patients will receive the same preemptive and postoperative multimodal medications for perioperative analgesia. All groups will receive standardized method of spinal anaesthesia and standardized method of intraoperative sedation for the surgery. Intravenous patient controlled analgesia (PCA) with morphine will be given for 48h to patient as rescue analgesia.

Inclusion Criterias

Planned use of spinal anaesthesia
Scheduled for elective total knee arthroplasty
Signed written informed consent
...
Planned use of spinal anaesthesia
Scheduled for elective total knee arthroplasty
Signed written informed consent
Cognitive sound to use assessment tools
Diagnosis of primary osteoarthritis

Exclusion Criterias

Patient outside range of 30 to 80 yrs old
Cognitive impairment/ inability to use the outcome assessment tools
Patients refusing to give consents
...
Patient outside range of 30 to 80 yrs old
Cognitive impairment/ inability to use the outcome assessment tools
Patients refusing to give consents
Non-chinese population
drug abuser
Moderate or severe renal impairment (serum creatinine > 160 micromol/l)
Scheduled for revision total knee replacement
severe cardiovascular disease (unstable angina, second or third degree heart block)
Pre-operative history of neurological abnormality in the ipsilateral leg e.g. history of stroke, neurogenic pain or previous nerve injury.
Contraindications to regional anesthesia
Allergy or contraindication to drugs used in this study: morphine, Non-steroidal anti-inflammatory drugs (NSAID) such as ketorolac , diclofenac, dihydrocodeine, local anaesthetics (lignocaine, ropivacaine, bupivacaine), epinephrine
pre-existing neurologic disease including psychiatric disorder

Locations

Kowloon
Kowloon

Tracking Information

NCT #
NCT01973530
Collaborators
Not Provided
Investigators
  • Principal Investigator: Eric So, FHKCA FHKAM Queen Elizabeth Hospital, Hospital Authority
  • Eric So, FHKCA FHKAM Queen Elizabeth Hospital, Hospital Authority