Recruitment

Recruitment Status
Completed

Inclusion Criterias

Ocular Surface Disease Index > 12<23 and age >59 yrs
Ocular Surface Disease Index > 12<23 and age >59 yrs

Exclusion Criterias

contact lens wear and use of other ophthalmic solutions with the exception of artificial tears
contact lens wear and use of other ophthalmic solutions with the exception of artificial tears

Summary

Conditions
Dry Eye
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 60 years and 125 years
Gender
Both males and females

Description

Oxidative stress is the result of an imbalance between the production of reactive oxygen species (ROS) and antioxidant systems . The eye is constantly exposed to solar UV radiation which is the major inducer of ROS production and therefore oxidative stress has been implicated in the pathogenesis of ...

Oxidative stress is the result of an imbalance between the production of reactive oxygen species (ROS) and antioxidant systems . The eye is constantly exposed to solar UV radiation which is the major inducer of ROS production and therefore oxidative stress has been implicated in the pathogenesis of several eye disease, including dry eye. Xanthan gum is a complex exopolysaccharide utilized as a food additive. Its chemical structure shows a capacity to react with ROS indicating a role as an anti-oxidative molecule. In the present study aging patients with dry eye will be enrolled. Signs and symptoms of dry eye as well as levels of oxidative stress in tear will be evaluated afte 30 days of treatment with eye drops containing carboxymethylcellulose or xanthan gum.

Inclusion Criterias

Ocular Surface Disease Index > 12<23 and age >59 yrs
Ocular Surface Disease Index > 12<23 and age >59 yrs

Exclusion Criterias

contact lens wear and use of other ophthalmic solutions with the exception of artificial tears
contact lens wear and use of other ophthalmic solutions with the exception of artificial tears

Locations

Messina
Messina

Tracking Information

NCT #
NCT01959854
Collaborators
Not Provided
Investigators
  • Principal Investigator: Pasquale Aragona, MD University of Messina (ITALY)
  • Pasquale Aragona, MD University of Messina (ITALY)