Recruitment

Recruitment Status
Completed
Estimated Enrollment
50

Inclusion Criterias

assigned to a diuretic arm
participation in the parent trial PEAR (201-2005) or PEAR2 (271-2010)
assigned to a diuretic arm
participation in the parent trial PEAR (201-2005) or PEAR2 (271-2010)

Exclusion Criterias

assigned to a beta blocker arm
no participation in the parent trial PEAR (201-2005) or PEAR2 (271-2010)
assigned to a beta blocker arm
no participation in the parent trial PEAR (201-2005) or PEAR2 (271-2010)

Summary

Conditions
Hypertension
Type
Observational
Design
  • Observational Model: Cohort
  • Time Perspective: Cross-Sectional

Participation Requirements

Age
Between 18 years and 75 years
Gender
Both males and females

Description

If the patient decide to participate in this study, they will have 1 visit for the study that will include a blood draw. Upon arrival to the clinic, the study will be explained to the patient in detail. The patient will be asked at that time to sign this consent form. The patient will have the oppor...

If the patient decide to participate in this study, they will have 1 visit for the study that will include a blood draw. Upon arrival to the clinic, the study will be explained to the patient in detail. The patient will be asked at that time to sign this consent form. The patient will have the opportunity to ask questions and the research staff will answer those questions. If the patient decides to participate in this study and sign a consent form, then a blood sample will be collected from a vein in the arm. A total of 2 teaspoons full of blood will be drawn for the study. During this visit, in addition to collecting a blood sample, patients will be asked about their medical history and medications they are currently taking, and will have their vital signs assessed, including blood pressure, pulse, and temperature. Blood will be drawn by a trained nurse or a phlebotomist at a family medicine clinic in Gainesville, Florida. The blood sample will be further processed in laboratories at the University of Florida, for the establishment of iPS cells. iPS cells will retain the patient's genetic makeup which makes them useful for research. Several experiments will be conducted on these cells that will provide data that can be used to learn more about how genetic markers can lead to differences in blood pressure response to medicines. These cells will be used for up to 8 years.

Inclusion Criterias

assigned to a diuretic arm
participation in the parent trial PEAR (201-2005) or PEAR2 (271-2010)
assigned to a diuretic arm
participation in the parent trial PEAR (201-2005) or PEAR2 (271-2010)

Exclusion Criterias

assigned to a beta blocker arm
no participation in the parent trial PEAR (201-2005) or PEAR2 (271-2010)
assigned to a beta blocker arm
no participation in the parent trial PEAR (201-2005) or PEAR2 (271-2010)

Locations

Gainesville, Florida, 32610
Gainesville, Florida, 32610

Tracking Information

NCT #
NCT01943383
Collaborators
Not Provided
Investigators
  • Principal Investigator: Julie A Johnson, PharmD University of Florida
  • Julie A Johnson, PharmD University of Florida