Recruitment

Recruitment Status
Terminated
Estimated Enrollment
43

Inclusion Criterias

Admitted to King's College Hospital within 48 hours of an acute infective pulmonary exacerbation characterised by an increase in respiratory symptoms requiring intravenous antibiotics
A diagnosis of CF (established by genotype or sweat sodium >70mmol/l or sweat chloride of >60 mmol/l
Admitted to King's College Hospital within 48 hours of an acute infective pulmonary exacerbation characterised by an increase in respiratory symptoms requiring intravenous antibiotics
A diagnosis of CF (established by genotype or sweat sodium >70mmol/l or sweat chloride of >60 mmol/l

Exclusion Criterias

Oesophageal varices
Epilepsy
Acute respiratory failure
...
Oesophageal varices
Epilepsy
Acute respiratory failure
Active tuberculosis
Pulmonary embolism
Ascending aortic aneurysm
Acute diarrhoea
Severe hypertension (systolic >200 mm Hg, diastolic >120 mm Hg)
Current pulmonary embolism
Current severe haemoptysis
Recent brain, eye, ear, ENT surgery
Current or recent pneumothorax
Rib fractures
Myocardial infarction
Inability to give consent
Recent thoracic upper gastro-intestinal tract or facial surgery
Haemodynamic instability (including severe right heart failure with hypotension)
Pregnancy
Angina
Ineffective cough
Confusion/dementia

Summary

Conditions
Cystic Fibrosis
Type
Interventional
Phase
Phase 2
Design
  • Allocation: Randomized
  • Intervention Model: Crossover Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 16 years and 125 years
Gender
Both males and females

Inclusion Criterias

Admitted to King's College Hospital within 48 hours of an acute infective pulmonary exacerbation characterised by an increase in respiratory symptoms requiring intravenous antibiotics
A diagnosis of CF (established by genotype or sweat sodium >70mmol/l or sweat chloride of >60 mmol/l
Admitted to King's College Hospital within 48 hours of an acute infective pulmonary exacerbation characterised by an increase in respiratory symptoms requiring intravenous antibiotics
A diagnosis of CF (established by genotype or sweat sodium >70mmol/l or sweat chloride of >60 mmol/l

Exclusion Criterias

Oesophageal varices
Epilepsy
Acute respiratory failure
...
Oesophageal varices
Epilepsy
Acute respiratory failure
Active tuberculosis
Pulmonary embolism
Ascending aortic aneurysm
Acute diarrhoea
Severe hypertension (systolic >200 mm Hg, diastolic >120 mm Hg)
Current pulmonary embolism
Current severe haemoptysis
Recent brain, eye, ear, ENT surgery
Current or recent pneumothorax
Rib fractures
Myocardial infarction
Inability to give consent
Recent thoracic upper gastro-intestinal tract or facial surgery
Haemodynamic instability (including severe right heart failure with hypotension)
Pregnancy
Angina
Ineffective cough
Confusion/dementia

Locations

London, SE5 9RS
London, SE5 9RS

Tracking Information

NCT #
NCT01923753
Collaborators
Not Provided
Investigators
  • Principal Investigator: John Moxham, MD King's College Hospital NHS Trust
  • John Moxham, MD King's College Hospital NHS Trust