Recruitment

Recruitment Status
Recruiting

Summary

Conditions
  • Bile Duct Cancer
  • Cholangiocarcinoma
  • Colorectal Neoplasms
  • Gastric Neoplasms
  • Pancreas Cancer
Type
Observational
Design
  • Observational Model: Cohort
  • Time Perspective: Prospective

Participation Requirements

Min Age
2
Max Age
125
Gender
Both

Description

Background: Recent advances and insights into the molecular pathogenesis of cancer have led to the development of novel molecular and biologic targeted therapies for the treatment of advanced cancer patients. A critical challenge in extending these studies involves the identification and validation ...

Background: Recent advances and insights into the molecular pathogenesis of cancer have led to the development of novel molecular and biologic targeted therapies for the treatment of advanced cancer patients. A critical challenge in extending these studies involves the identification and validation of new therapeutic targets for future cancer therapies. As Surgical Oncologists at the NCI, we have an interest in identifying novel molecular and biologic targets to facilitate the development of future cancer therapies. In addition, we have the primary responsibility for providing surgical consultative services to the NIH. As such, we are uniquely positioned to acquire and perform important studies on solid tumor tissue to help identify therapeutic targets that may have significant clinical ramifications. Objectives: To collect biologic samples from patients undergoing diagnostic, preventative, or therapeutic interventions for premalignant, primary or metastatic solid tumors for the purpose of identifying novel molecular and biologic therapeutic targets. Eligibility: Patients age >= 2 years and older with radiographic or clinical suspicion of, genetic predisposition for, biochemical evidence of, or histologically/cytologically proven solid neoplasms who require diagnostic, preventative, or therapeutic intervention as a part of the diagnosis and/or treatment and/or follow up for their neoplasm. Note: Patients >= 2 years of age and under 18 years of age may only participate in research sample collection if the tissue acquisition is performed during a clinically indicated surgical procedure, and the sampling of tissue, blood or urine does not add risk to the clinically indicated procedures. Patients without solid tumors in whom a diagnostic, preventative, or therapeutic intervention is being performed, but for whom surgical quality and safety outcomes data are generated. Patients should have laboratory and physical examination parameters within acceptable limits by standard of practice guidelines prior to planned intervention. Design: A tissue acquisition trial in which tissues will be obtained at the time of intervention. No investigational therapy will be given. It is anticipated that 1000 patients will be enrolled over a period of 10 years.

Locations

Bethesda, Maryland, 20892
Bethesda, Maryland, 20892

Tracking Information

NCT #
NCT01915225
Collaborators
Not Provided
Investigators
  • Principal Investigator: Jeremy L Davis, M.D. National Cancer Institute (NCI)
  • Jeremy L Davis, M.D. National Cancer Institute (NCI)