Identification of Novel Skeletal Muscle-derived Factors That Promote Lipid Oxidation (Columbus)
Last updated on July 2021Recruitment
- Recruitment Status
- Active, not recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Disorder of Lipid Storage and Metabolism
- Lipid Metabolism Disorders
- Metabolic Disorder
- Obesity
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: Non-RandomizedIntervention Model: Parallel AssignmentMasking: None (Open Label)Primary Purpose: Basic Science
Participation Requirements
- Age
- Between 18 years and 40 years
- Gender
- Both males and females
Description
Study Objectives: To identify specific changes in messenger ribonucleic acid (mRNA)/micro ribonucleic acid (miRNA) expression in muscle associated with higher or lower relative measures of mitochondrial capacity and fat oxidation. To identify secreted factors/miRNAs that specifically relate to the m...
Study Objectives: To identify specific changes in messenger ribonucleic acid (mRNA)/micro ribonucleic acid (miRNA) expression in muscle associated with higher or lower relative measures of mitochondrial capacity and fat oxidation. To identify secreted factors/miRNAs that specifically relate to the metabolic response of muscle and that are present after a single initial bout of exercise. To collect the appropriate clinical samples (muscle and adipose tissue, plasma/serum) to enable validation of myokines associated with changes in oxygen consumption/mitochondrial content via in vivo and in vitro discovery efforts.
Tracking Information
- NCT #
- NCT01911091
- Collaborators
- Sanford-Burnham Medical Research Institute
- Takeda
- Investigators
- Principal Investigator: Steven R Smith, MD Translational Research Institute for Metabolism and Diabetes
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