Recruitment

Recruitment Status
Unknown status

Inclusion Criterias

COPD (FEV1/FVC < 0.70 and FEV1 < 0.80 predicted
Smoking history > 15 pack-years
Healthy subjects: no evidence of airways obstruction (FEV1/FVC > 0.70 and FEV1 > 0.80 predicted)
COPD (FEV1/FVC < 0.70 and FEV1 < 0.80 predicted
Smoking history > 15 pack-years
Healthy subjects: no evidence of airways obstruction (FEV1/FVC > 0.70 and FEV1 > 0.80 predicted)

Exclusion Criterias

Recent exacerbation (< 3 months)
Unstable cardiac disease
Physical activity score > 9 in the Voorips questionnaire
...
Recent exacerbation (< 3 months)
Unstable cardiac disease
Physical activity score > 9 in the Voorips questionnaire
Recent cancer (< 3 years)
Diabetes
Thigh skinfold thickness > 15 mm
Chronic hypoxemia and/or hypercapnia (PaO2 < 60 mmHg or SpO2 < 88% at rest and/or PaCO2 > 45 mmHg)
Myopathy, neuromuscular or articular disease
BMI > 30
Regular physical activity or exercise training program in the last 2 months
Absolute contraindications to exercise testing

Summary

Conditions
Pulmonary Disease, Chronic Obstructive
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Crossover Assignment
  • Masking: Single (Participant)
  • Primary Purpose: Basic Science

Participation Requirements

Age
Between 50 years and 75 years
Gender
Both males and females

Inclusion Criterias

COPD (FEV1/FVC < 0.70 and FEV1 < 0.80 predicted
Smoking history > 15 pack-years
Healthy subjects: no evidence of airways obstruction (FEV1/FVC > 0.70 and FEV1 > 0.80 predicted)
COPD (FEV1/FVC < 0.70 and FEV1 < 0.80 predicted
Smoking history > 15 pack-years
Healthy subjects: no evidence of airways obstruction (FEV1/FVC > 0.70 and FEV1 > 0.80 predicted)

Exclusion Criterias

Recent exacerbation (< 3 months)
Unstable cardiac disease
Physical activity score > 9 in the Voorips questionnaire
...
Recent exacerbation (< 3 months)
Unstable cardiac disease
Physical activity score > 9 in the Voorips questionnaire
Recent cancer (< 3 years)
Diabetes
Thigh skinfold thickness > 15 mm
Chronic hypoxemia and/or hypercapnia (PaO2 < 60 mmHg or SpO2 < 88% at rest and/or PaCO2 > 45 mmHg)
Myopathy, neuromuscular or articular disease
BMI > 30
Regular physical activity or exercise training program in the last 2 months
Absolute contraindications to exercise testing

Locations

Québec, Quebec, G1V 4G5
Québec, Quebec, G1V 4G5

Tracking Information

NCT #
NCT01909544
Collaborators
Canadian Lung Association
Investigators
  • Principal Investigator: François Maltais, MD Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
  • François Maltais, MD Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval