Recruitment

Recruitment Status
Unknown status

Inclusion Criterias

Patients undergo screening endoscopy or histologically verified esophageal squamous intraepithelial neoplasia before.
Patients aged between 50 and 80 years old
Patients undergo screening endoscopy or histologically verified esophageal squamous intraepithelial neoplasia before.
Patients aged between 50 and 80 years old

Exclusion Criterias

Impaired renal function
History of upper GI tract surgery
Allergy to fluorescein sodium
...
Impaired renal function
History of upper GI tract surgery
Allergy to fluorescein sodium
Coagulopathy or acute GI bleeding
Advanced esophageal, gastric or duodenal cancer
Inability to provide informed consent.
Pregnant or breast-feeding (for females)

Summary

Conditions
Esophageal Squamous Intraepithelial Neoplasia
Type
Observational
Design
  • Observational Model: Cohort
  • Time Perspective: Retrospective

Participation Requirements

Age
Between 50 years and 80 years
Gender
Both males and females

Description

Probe-based confocal laser endomicroscopy (pCLE; Cellvizio, Mauna Kea Technologies, Paris, France) is a newly developed endoscopic device and has shown its value for diagnosing Barrett's esophagus, colonal polyps and etc. However, none research has focus on early esophageal squamous neoplasia until ...

Probe-based confocal laser endomicroscopy (pCLE; Cellvizio, Mauna Kea Technologies, Paris, France) is a newly developed endoscopic device and has shown its value for diagnosing Barrett's esophagus, colonal polyps and etc. However, none research has focus on early esophageal squamous neoplasia until now. Previous diagnosis of early esophageal neoplasia is based on the lugol staining which is time wasting and have many adverse events.Other researches have suggested virtual chromoendoscopys are beneficial for screening esophageal tumors. Therefore, the aim of the present study is 1.To investigate the diagnosing value of pCLE for early esophageal squamous neoplasia according to the surface maturation scoring(SMS) diagnostic criteria and 2. To assess the detection rate of early esophageal squamous neoplasia by virtual chromoendoscopy(I-SCAN).

Inclusion Criterias

Patients undergo screening endoscopy or histologically verified esophageal squamous intraepithelial neoplasia before.
Patients aged between 50 and 80 years old
Patients undergo screening endoscopy or histologically verified esophageal squamous intraepithelial neoplasia before.
Patients aged between 50 and 80 years old

Exclusion Criterias

Impaired renal function
History of upper GI tract surgery
Allergy to fluorescein sodium
...
Impaired renal function
History of upper GI tract surgery
Allergy to fluorescein sodium
Coagulopathy or acute GI bleeding
Advanced esophageal, gastric or duodenal cancer
Inability to provide informed consent.
Pregnant or breast-feeding (for females)

Locations

Jinan, Shandong, 250012
Jinan, Shandong, 250012

Tracking Information

NCT #
NCT01909518
Collaborators
Not Provided
Investigators
  • Principal Investigator: Yanqing Li, MD. PhD. Qilu Hospital, Shandong University
  • Yanqing Li, MD. PhD. Qilu Hospital, Shandong University