Recruitment

Recruitment Status
Unknown status

Inclusion Criterias

Artefact-free simultaneous measurement of respiratory rate, pCO2 (transcutaneous probe), body temperature (rectal probe), and heart rate during change of body temperature of ≥1.0 degree C.
Change of body temperature of ≥1.0 degree C during the monitoring period
Provision of written informed consent by the parents or guardians of the child
...
Artefact-free simultaneous measurement of respiratory rate, pCO2 (transcutaneous probe), body temperature (rectal probe), and heart rate during change of body temperature of ≥1.0 degree C.
Change of body temperature of ≥1.0 degree C during the monitoring period
Provision of written informed consent by the parents or guardians of the child
50% of study population: never had a febrile seizure
50% of study population: simple or complex febrile seizure within one day of investigation
Febrile illness with body temperature ≥38.0 degree C

Exclusion Criterias

Retarded psychomotor development
Therapeutic increase of inspiratory oxygen concentrations during the observational period
Severe other organ disease
...
Retarded psychomotor development
Therapeutic increase of inspiratory oxygen concentrations during the observational period
Severe other organ disease
Permanent medication for chronic disorder
Past history of neonatal seizures
Past history of afebrile seizures
Cardiologic disease
Chronic respiratory disease

Summary

Conditions
  • Febrile Illness in Children
  • Seizures, Febrile
Type
Observational
Design
  • Observational Model: Case-Control
  • Time Perspective: Prospective

Participation Requirements

Age
Younger than 35 years
Gender
Both males and females

Description

The aim of the study is the continuous non-invasive monitoring of body temperature respiratory rate transcutaneous pCO2 heart rate pulsoxymetric SaO2 (arterial oxygen saturation) during a febrile illness in children without febrile seizures and in children who had suffered a febrile seizure during t...

The aim of the study is the continuous non-invasive monitoring of body temperature respiratory rate transcutaneous pCO2 heart rate pulsoxymetric SaO2 (arterial oxygen saturation) during a febrile illness in children without febrile seizures and in children who had suffered a febrile seizure during the actual febrile illness. Children will be recruited from the emergency units of the Charité University Hospital and a large Community Hospital, matched according to age, gender and the cause of their febrile illness and their data will enter final analysis if their body temperature rose at least once to or above 38.0 degree C and changed more than 1.0 degree C during the observational period.

Inclusion Criterias

Artefact-free simultaneous measurement of respiratory rate, pCO2 (transcutaneous probe), body temperature (rectal probe), and heart rate during change of body temperature of ≥1.0 degree C.
Change of body temperature of ≥1.0 degree C during the monitoring period
Provision of written informed consent by the parents or guardians of the child
...
Artefact-free simultaneous measurement of respiratory rate, pCO2 (transcutaneous probe), body temperature (rectal probe), and heart rate during change of body temperature of ≥1.0 degree C.
Change of body temperature of ≥1.0 degree C during the monitoring period
Provision of written informed consent by the parents or guardians of the child
50% of study population: never had a febrile seizure
50% of study population: simple or complex febrile seizure within one day of investigation
Febrile illness with body temperature ≥38.0 degree C

Exclusion Criterias

Retarded psychomotor development
Therapeutic increase of inspiratory oxygen concentrations during the observational period
Severe other organ disease
...
Retarded psychomotor development
Therapeutic increase of inspiratory oxygen concentrations during the observational period
Severe other organ disease
Permanent medication for chronic disorder
Past history of neonatal seizures
Past history of afebrile seizures
Cardiologic disease
Chronic respiratory disease

Locations

Berlin, 13353
Berlin, 13353

Tracking Information

NCT #
NCT01906619
Collaborators
Sana-Klinikum Lichtenberg
Investigators
  • Principal Investigator: Markus Schuelke, MD Charite University, Berlin, Germany
  • Markus Schuelke, MD Charite University, Berlin, Germany