Recruitment

Recruitment Status
Completed
Estimated Enrollment
52500

Inclusion Criterias

Visited by a CHiP team and offered testing during the second round of home-based testing
Resident in the cluster during the second round of testing
Able and willing to provide informed consent
...
Visited by a CHiP team and offered testing during the second round of home-based testing
Resident in the cluster during the second round of testing
Able and willing to provide informed consent
At least 18 years of age

Exclusion Criterias

Known HIV infected from CHiP data.
Individuals belonging to the Population Cohort or other case-control studies
Known HIV infected from CHiP data.
Individuals belonging to the Population Cohort or other case-control studies

Summary

Conditions
HIV
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Prevention

Participation Requirements

Age
Between 18 years and 44 years
Gender
Both males and females

Description

HIV Prevention Trials Network (HPTN) 071 (PopART) will investigate the impact on HIV incidence of universal voluntary HIV counseling and testing (with referral to care) provided to a community through a house-to-house campaign, in combination with early ART for individuals who are HIV-positive, and ...

HIV Prevention Trials Network (HPTN) 071 (PopART) will investigate the impact on HIV incidence of universal voluntary HIV counseling and testing (with referral to care) provided to a community through a house-to-house campaign, in combination with early ART for individuals who are HIV-positive, and other proven preventive interventions. The design of HPTN 071 (PopART) will allow the study team to distinguish between the impact of universal testing with referral for HIV care in accordance with national guidelines, and the impact of universal testing with referral for early ART initiation for those with HIV infection. In addition, HPTN 071 (PopART) will determine if a program of universal voluntary testing, including early ART initiation, is feasible and acceptable when delivered on a large scale to entire communities. Evaluating the effectiveness of universal voluntary HIV counseling and testing with the offer of early ART is a key global health priority.

Inclusion Criterias

Visited by a CHiP team and offered testing during the second round of home-based testing
Resident in the cluster during the second round of testing
Able and willing to provide informed consent
...
Visited by a CHiP team and offered testing during the second round of home-based testing
Resident in the cluster during the second round of testing
Able and willing to provide informed consent
At least 18 years of age

Exclusion Criterias

Known HIV infected from CHiP data.
Individuals belonging to the Population Cohort or other case-control studies
Known HIV infected from CHiP data.
Individuals belonging to the Population Cohort or other case-control studies

Locations

Cape Town, Western Cape, 7505
Lusaka
Cape Town, Western Cape, 7505
Lusaka

Tracking Information

NCT #
NCT01900977
Collaborators
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • National Institute of Mental Health (NIMH)
  • National Institute on Drug Abuse (NIDA)
  • Office of the U.S. Global AIDS Coordinator
  • The International Initiative for Impact Evaluation (3ie) with support from Bill & Melinda Gates Foundation
  • London School of Hygiene and Tropical Medicine
  • Imperial College London
  • Zambart
  • Desmond Tutu TB Centre
Investigators
  • Study Chair: Richard Hayes, BSc, MSc, DSc London School of Hygiene and Tropical Medicine Study Chair: Sarah Fidler, MBBS, PhD Imperial College London Principal Investigator: Helen Ayles, BSc, MBBS, MSc, PhD London School of Hygiene and Tropical Medicine Principal Investigator: Nulda Beyers, MBChB, FCP, MSc, PhD Stellenbosch Univeristy Principal Investigator: Peter Bock, MD, MRCP, MRCGP, MPH, PhD University of Stellenbosch
  • Study Chair: Richard Hayes, BSc, MSc, DSc London School of Hygiene and Tropical Medicine Study Chair: Sarah Fidler, MBBS, PhD Imperial College London Helen Ayles, BSc, MBBS, MSc, PhD London School of Hygiene and Tropical Medicine Principal Investigator: Nulda Beyers, MBChB, FCP, MSc, PhD Stellenbosch Univeristy Principal Investigator: Peter Bock, MD, MRCP, MRCGP, MPH, PhD University of Stellenbosch