Recruitment

Recruitment Status
Completed

Inclusion Criterias

age 50-85 years old
primary osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty
age 50-85 years old
primary osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty

Exclusion Criterias

cognitive function impairment
history of drug allergies; local anaesthesia, Non-steroidal anti-inflammatory drugs, morphine, epinephrine
unable to perform spinal anaesthesia
...
cognitive function impairment
history of drug allergies; local anaesthesia, Non-steroidal anti-inflammatory drugs, morphine, epinephrine
unable to perform spinal anaesthesia
liver impairment, gastrointestinal bleeding
renal impairment (creatinine clearance < 30 mL/min)

Summary

Conditions
Postoperative Pain
Type
Interventional
Phase
Phase 4
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 50 years and 85 years
Gender
Both males and females

Description

Many studies have to determine the efficacy of periarticular multimodal drug injection or single local anaesthetic drug comparing with placebo for pain controlled in TKA. But in this study would like to determine which one of both drugs are more efficacy. In multimodal drug injection consist of levo...

Many studies have to determine the efficacy of periarticular multimodal drug injection or single local anaesthetic drug comparing with placebo for pain controlled in TKA. But in this study would like to determine which one of both drugs are more efficacy. In multimodal drug injection consist of levobupivacaine, morphine, ketorolac and epinephrine while single anaesthetic drug has levobupivacaine and epinephrine.

Inclusion Criterias

age 50-85 years old
primary osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty
age 50-85 years old
primary osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty

Exclusion Criterias

cognitive function impairment
history of drug allergies; local anaesthesia, Non-steroidal anti-inflammatory drugs, morphine, epinephrine
unable to perform spinal anaesthesia
...
cognitive function impairment
history of drug allergies; local anaesthesia, Non-steroidal anti-inflammatory drugs, morphine, epinephrine
unable to perform spinal anaesthesia
liver impairment, gastrointestinal bleeding
renal impairment (creatinine clearance < 30 mL/min)

Locations

Khlong Luang, Pathumthani, 12120
Khlong Luang, Pathumthani, 12120

Tracking Information

NCT #
NCT01898052
Collaborators
Not Provided
Investigators
  • Principal Investigator: Supakit Kanitnate, M.D. orthopaedics department
  • Supakit Kanitnate, M.D. orthopaedics department