Recruitment

Recruitment Status
Unknown status

Inclusion Criterias

Normotensive (SBP<140mmHg, DBP <90mmHg)
Post-menopausal or not pregnant women
BMI 18.5 - 25 kg/m2
Normotensive (SBP<140mmHg, DBP <90mmHg)
Post-menopausal or not pregnant women
BMI 18.5 - 25 kg/m2

Exclusion Criterias

Allergy or sensitivity to test meals
Chronic use of medications or fibre
History of liver or kidney disease, diabetes, hypertension, stroke or myocardial infarctions, thyroid disease, celiac /gastrointestinal disease, HIV positive or AIDS
...
Allergy or sensitivity to test meals
Chronic use of medications or fibre
History of liver or kidney disease, diabetes, hypertension, stroke or myocardial infarctions, thyroid disease, celiac /gastrointestinal disease, HIV positive or AIDS
Swallowing difficulties
GI conditions affecting stomach pH
Must not be enrolled in another study

Summary

Conditions
  • Diabetes
  • Healthy
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Crossover Assignment
  • Masking: Triple (Participant, Investigator, Outcomes Assessor)

Participation Requirements

Age
Between 19 years and 75 years
Gender
Both males and females

Description

Literature to date points to beneficial glycemic effects from consumption of soluble fibre; however, whole grain products consumption is below recommendations possibly due to the presence of unappealing characteristic organoleptic properties. White, refined products are still the choice of the gener...

Literature to date points to beneficial glycemic effects from consumption of soluble fibre; however, whole grain products consumption is below recommendations possibly due to the presence of unappealing characteristic organoleptic properties. White, refined products are still the choice of the general public. As such, we propose to investigate the feasibility of increasing health benefits of commonly consumed white, refined carbohydrate products by incorporating a soluble fibre blend. This research is important to determine the feasibility of developing fibre enriched carbohydrate foods that maintains the original organoleptic properties and is effective in reducing postprandial blood glucose response. 35 subjects will be recruited in phase I to complete a sensory evaluation on the test foods. Following tasting of the control and fibre-enriched samples, data on each subjects' liking or disliking will be collected through a 9-point hedonic scale. An acute crossover RCT will be conducted in phase II by 10 healthy individuals. Subjects will be randomized to consume one the treatments at each visit and blood glucose levels over 120min and satiety scores will be measured.

Inclusion Criterias

Normotensive (SBP<140mmHg, DBP <90mmHg)
Post-menopausal or not pregnant women
BMI 18.5 - 25 kg/m2
Normotensive (SBP<140mmHg, DBP <90mmHg)
Post-menopausal or not pregnant women
BMI 18.5 - 25 kg/m2

Exclusion Criterias

Allergy or sensitivity to test meals
Chronic use of medications or fibre
History of liver or kidney disease, diabetes, hypertension, stroke or myocardial infarctions, thyroid disease, celiac /gastrointestinal disease, HIV positive or AIDS
...
Allergy or sensitivity to test meals
Chronic use of medications or fibre
History of liver or kidney disease, diabetes, hypertension, stroke or myocardial infarctions, thyroid disease, celiac /gastrointestinal disease, HIV positive or AIDS
Swallowing difficulties
GI conditions affecting stomach pH
Must not be enrolled in another study

Locations

Toronto, Ontario, M5BW8
Toronto, Ontario, M5BW8

Tracking Information

NCT #
NCT01898026
Collaborators
Not Provided
Investigators
  • Principal Investigator: Vladimir Vuksan, PhD St. Michael's & University of Toronto
  • Vladimir Vuksan, PhD St. Michael's & University of Toronto