Recruitment

Recruitment Status
Completed

Inclusion Criterias

Subjects of both genders aged of at least 18 years
Registered at the National List of persons taking part in clinical research
Signed consent form
...
Subjects of both genders aged of at least 18 years
Registered at the National List of persons taking part in clinical research
Signed consent form
Perfect understanding of the instructions and of sensory scaling
Prior medical examination

Exclusion Criterias

Any current or past disease, in particular respiratory, neurological and psychiatric disorders
No affiliation to a social security system.
Pregnancy or lactation
...
Any current or past disease, in particular respiratory, neurological and psychiatric disorders
No affiliation to a social security system.
Pregnancy or lactation
Vulnerable people as defined in the provisions relating to biomedical researches and described in the Code of Public Health.
Unable to cooperate
Regular use of drugs, especially those having an impact on respiratory, neurological systems (most specifically those with an effect on the central nervous system)
Unwilling to participate

Summary

Conditions
Dyspnea
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Single (Participant)

Participation Requirements

Age
Between 18 years and 125 years
Gender
Both males and females

Description

Dyspnea will be induced by breathing through a combination of an external resistive load and a long tube (inducing CO2 rebreathing) (resulting in a sensation of both increased respiratory effort and air hunger). tDCS will be applied during 15 minutes either over the motor/premotor or over the insula...

Dyspnea will be induced by breathing through a combination of an external resistive load and a long tube (inducing CO2 rebreathing) (resulting in a sensation of both increased respiratory effort and air hunger). tDCS will be applied during 15 minutes either over the motor/premotor or over the insular cortex (i.e. 2 brain regions that have previously been shown to be involved in dyspnea perception and/or modulation) in 2 parallel groups of healthy subjects. For each study group, the effect of tDCS on dyspnea perception and on respiratory parameters will be compared between 2 active (anodal and cathodal) and a sham tDCS stimulation (placebo).

Inclusion Criterias

Subjects of both genders aged of at least 18 years
Registered at the National List of persons taking part in clinical research
Signed consent form
...
Subjects of both genders aged of at least 18 years
Registered at the National List of persons taking part in clinical research
Signed consent form
Perfect understanding of the instructions and of sensory scaling
Prior medical examination

Exclusion Criterias

Any current or past disease, in particular respiratory, neurological and psychiatric disorders
No affiliation to a social security system.
Pregnancy or lactation
...
Any current or past disease, in particular respiratory, neurological and psychiatric disorders
No affiliation to a social security system.
Pregnancy or lactation
Vulnerable people as defined in the provisions relating to biomedical researches and described in the Code of Public Health.
Unable to cooperate
Regular use of drugs, especially those having an impact on respiratory, neurological systems (most specifically those with an effect on the central nervous system)
Unwilling to participate

Locations

Garches, 92380
Garches, 92380

Tracking Information

NCT #
NCT01892553
Collaborators
Adep Assistance
Investigators
  • Principal Investigator: CLAUDINE PEIFFER, MD PHD HOPITAL RAYMOND POINCARE
  • CLAUDINE PEIFFER, MD PHD HOPITAL RAYMOND POINCARE