Study of Gene Expression Profiling and Immunological Mechanism Affects the Response of Immunotherapy
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Malignant Tumor
- Type
- Observational
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 80 years
- Gender
- Both males and females
Description
The patients with malignant cavity effusion are treated with dendritic cells (DC) plus cytokine induced killer cells (CIK) locally. Malignant cavity effusion from cancer patients is obtained through puncture and is centrifugalized to get supernatant fluid and enrich cancer cells before and after the...
The patients with malignant cavity effusion are treated with dendritic cells (DC) plus cytokine induced killer cells (CIK) locally. Malignant cavity effusion from cancer patients is obtained through puncture and is centrifugalized to get supernatant fluid and enrich cancer cells before and after the therapy. The enriched cancer cells which are flash frozen, as well as the supernatant, are stored at -80°C until processing. The T-Cell Receptor/B-Cell Receptor gene expression in cavity effusion is detected by micro-array to explore the mechanism that DC-CIK immunotherapy controls the malignant cavity effusion. Statistical analysis is performed using unsupervised hierarchical cluster.
Tracking Information
- NCT #
- NCT01884168
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Jun Ren, MD, PhD Capital Medical University Cancer Center /Beijing Shijitan Hospital
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