Recruitment

Recruitment Status
Completed

Inclusion Criterias

Task specific Focal Hand Dystonia
Task specific Focal Hand Dystonia

Exclusion Criterias

botulinum toxin within the past three months
implanted medical devices
seizure history
...
botulinum toxin within the past three months
implanted medical devices
seizure history
medication for dystonia
pregnancy
any neurologic condition other than FHD

Summary

Conditions
Dystonia, Focal, Task-specific
Type
Interventional
Phase
Phase 1
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 21 years and 75 years
Gender
Both males and females

Description

Purpose: The ability of low-frequency repetitive transcranial magnetic stimulation (rTMS) to enhance intracortical inhibition has motivated its use as a potential therapeutic intervention in focal hand dystonia (FHD). In this preliminary investigation, we assessed the physiologic and behavioral effe...

Purpose: The ability of low-frequency repetitive transcranial magnetic stimulation (rTMS) to enhance intracortical inhibition has motivated its use as a potential therapeutic intervention in focal hand dystonia (FHD). In this preliminary investigation, we assessed the physiologic and behavioral effects of multiple sessions of rTMS in FHD. Methods: 12 patients with FHD underwent five daily-sessions of 1 Hz rTMS to contralateral dorsal premotor cortex (dPMC). Patients held a pencil and made movements that did not elicit dystonic symptoms during rTMS. We hypothesized that an active but non-dystonic motor state would increase beneficial effects of rTMS. Five additional patients received sham-rTMS protocol. The area under curve (AUC) of the motor evoked potentials and the cortical silent period (CSP) were measured to assess changes in corticospinal excitability and intracortical inhibition, respectively. Behavioral measures included pen force and velocity during handwriting and subjective report.

Inclusion Criterias

Task specific Focal Hand Dystonia
Task specific Focal Hand Dystonia

Exclusion Criterias

botulinum toxin within the past three months
implanted medical devices
seizure history
...
botulinum toxin within the past three months
implanted medical devices
seizure history
medication for dystonia
pregnancy
any neurologic condition other than FHD

Locations

Minneapolis, Minnesota, 55455
Minneapolis, Minnesota, 55455

Tracking Information

NCT #
NCT01884064
Collaborators
  • Dystonia Medical Research Foundation
  • National Institutes of Health (NIH)
  • National Center for Research Resources (NCRR)
Investigators
  • Principal Investigator: Teresa J Kimberley, PhD, PT University of Minnesota
  • Teresa J Kimberley, PhD, PT University of Minnesota