Recruitment

Recruitment Status
Unknown status

Inclusion Criterias

Small vessel disease and associated cognitive impairment, diagnosed as VCIND;
Normal hepatic and renal function.
With good compliance.
...
Small vessel disease and associated cognitive impairment, diagnosed as VCIND;
Normal hepatic and renal function.
With good compliance.
Aged between 50-80, both gender;
Non-specific subjective symptoms (dizziness, somnolence, numbness in limbs) are acceptable.

Exclusion Criterias

Cardiac cerebral infarction.
Thrombocytopenic Purpura.
Allergic to aspirin or cilostazol.
...
Cardiac cerebral infarction.
Thrombocytopenic Purpura.
Allergic to aspirin or cilostazol.
Intracerebral Hemorrhage.
Cerebral infarction(>2cm).
History of hemorrhage in digestive system or surgery in past 3 months.
Clinical manifestations cannot attribute to small vessel disease.
Dementia.
Enrolled in other clinical trials in past 3 months.
Major depression or dysfunction in speech, visual ability, hearing or aphasia that would interfere with the cognitive assessment.
Aged above 80 or less than 50.
Lack of informed consent or compliance.
Major vascular lesion. (stenosis>50%).
Contraindications for MRI scan.
Previously on cilostazol treatment for more than 3 month.
Severe systematic organic impairment(cardiac, hepatic, renal dysfunction).

Summary

Conditions
Mild Cognitive Impairment
Type
Interventional
Design
  • Allocation: Non-Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 50 years and 80 years
Gender
Both males and females

Inclusion Criterias

Small vessel disease and associated cognitive impairment, diagnosed as VCIND;
Normal hepatic and renal function.
With good compliance.
...
Small vessel disease and associated cognitive impairment, diagnosed as VCIND;
Normal hepatic and renal function.
With good compliance.
Aged between 50-80, both gender;
Non-specific subjective symptoms (dizziness, somnolence, numbness in limbs) are acceptable.

Exclusion Criterias

Cardiac cerebral infarction.
Thrombocytopenic Purpura.
Allergic to aspirin or cilostazol.
...
Cardiac cerebral infarction.
Thrombocytopenic Purpura.
Allergic to aspirin or cilostazol.
Intracerebral Hemorrhage.
Cerebral infarction(>2cm).
History of hemorrhage in digestive system or surgery in past 3 months.
Clinical manifestations cannot attribute to small vessel disease.
Dementia.
Enrolled in other clinical trials in past 3 months.
Major depression or dysfunction in speech, visual ability, hearing or aphasia that would interfere with the cognitive assessment.
Aged above 80 or less than 50.
Lack of informed consent or compliance.
Major vascular lesion. (stenosis>50%).
Contraindications for MRI scan.
Previously on cilostazol treatment for more than 3 month.
Severe systematic organic impairment(cardiac, hepatic, renal dysfunction).

Locations

Shanghai, Shanghai, 200040
Shanghai, Shanghai, 200040

Tracking Information

NCT #
NCT01872858
Collaborators
Not Provided
Investigators
Not Provided