Recruitment

Recruitment Status
Completed

Inclusion Criterias

Male or female patients greater than 65 years of age
Male or female patients greater than 65 years of age

Exclusion Criterias

Patients with a known sensitivity/allergy to ropivacaine or amide-type local anaesthetics
Patients undergoing bilateral hip replacements
Patients who are not suitable for the Caledonian technique
...
Patients with a known sensitivity/allergy to ropivacaine or amide-type local anaesthetics
Patients undergoing bilateral hip replacements
Patients who are not suitable for the Caledonian technique
Patients with known heart, liver or kidney failure
Patients who refuse or are unable to give consent

Summary

Conditions
Osteoarthritis, Hip
Type
Observational
Design
  • Observational Model: Case-Only
  • Time Perspective: Prospective

Participation Requirements

Age
Between 65 years and 125 years
Gender
Both males and females

Description

Local anaesthetic (LA) toxicity may occur when the blood levels of a drug become particularly high. There is a need to confirm that the technique is safe to use. In addition, journal case reports may only describe serious side-effects of toxicity such as abnormal heart rhythms whilst more subtle cli...

Local anaesthetic (LA) toxicity may occur when the blood levels of a drug become particularly high. There is a need to confirm that the technique is safe to use. In addition, journal case reports may only describe serious side-effects of toxicity such as abnormal heart rhythms whilst more subtle clinical signs are rarely reported. The investigators would like to study whether or not toxic levels may be approached in some patients or whether more subtle toxicity symptoms and signs are missed. For example, irregular heartbeat, low blood pressure or confusion/agitation. Therefore, the investigators intend to study ropivacaine blood levels in patients receiving a total hip replacement in the Golden Jubilee National Hospital. A series of timed samples will be taken during the perioperative period. The anaesthesia and surgery will be performed as routine and no new treatment will be involved. Patient demographics, ropivacaine blood levels and clinical observations following LA administration will be collected.

Inclusion Criterias

Male or female patients greater than 65 years of age
Male or female patients greater than 65 years of age

Exclusion Criterias

Patients with a known sensitivity/allergy to ropivacaine or amide-type local anaesthetics
Patients undergoing bilateral hip replacements
Patients who are not suitable for the Caledonian technique
...
Patients with a known sensitivity/allergy to ropivacaine or amide-type local anaesthetics
Patients undergoing bilateral hip replacements
Patients who are not suitable for the Caledonian technique
Patients with known heart, liver or kidney failure
Patients who refuse or are unable to give consent

Locations

Clydebank, West Dunbartonshire, G81 4DY
Clydebank, West Dunbartonshire, G81 4DY

Tracking Information

NCT #
NCT01869946
Collaborators
  • B. Braun Medical Inc.
  • University of Strathclyde
Investigators
  • Principal Investigator: Michael Gill, MBChB NHS Research Scotland
  • Michael Gill, MBChB NHS Research Scotland