Recruitment

Recruitment Status
Completed
Estimated Enrollment
90

Inclusion Criterias

Diagnosis of WS confirmed by FISH or chromosomal microarray (WS only)
Availability of a parent or guardian to participate in the consent process (all WS, and controls <18yo)
M or F age 14-70yo
Diagnosis of WS confirmed by FISH or chromosomal microarray (WS only)
Availability of a parent or guardian to participate in the consent process (all WS, and controls <18yo)
M or F age 14-70yo

Exclusion Criterias

Known diabetes will preclude administration of the OGTT but not participation in other aspects of the study.
History of weight loss surgery or liposuction
Positive urine pregnancy test (females only)
...
Known diabetes will preclude administration of the OGTT but not participation in other aspects of the study.
History of weight loss surgery or liposuction
Positive urine pregnancy test (females only)
Obesity or abnormal fat distribution due to a known secondary cause (except WS) such as Cushing syndrome, HIV-infection, etc.
Use of weight-lowering drugs

Summary

Conditions
Williams Syndrome
Type
Observational
Design
  • Observational Model: Cohort
  • Time Perspective: Cross-Sectional

Participation Requirements

Age
Between 14 years and 70 years
Gender
Both males and females

Inclusion Criterias

Diagnosis of WS confirmed by FISH or chromosomal microarray (WS only)
Availability of a parent or guardian to participate in the consent process (all WS, and controls <18yo)
M or F age 14-70yo
Diagnosis of WS confirmed by FISH or chromosomal microarray (WS only)
Availability of a parent or guardian to participate in the consent process (all WS, and controls <18yo)
M or F age 14-70yo

Exclusion Criterias

Known diabetes will preclude administration of the OGTT but not participation in other aspects of the study.
History of weight loss surgery or liposuction
Positive urine pregnancy test (females only)
...
Known diabetes will preclude administration of the OGTT but not participation in other aspects of the study.
History of weight loss surgery or liposuction
Positive urine pregnancy test (females only)
Obesity or abnormal fat distribution due to a known secondary cause (except WS) such as Cushing syndrome, HIV-infection, etc.
Use of weight-lowering drugs

Locations

Boston, Massachusetts, 02114
Boston, Massachusetts, 02114

Tracking Information

NCT #
NCT01864304
Collaborators
Not Provided
Investigators
  • Principal Investigator: Takara Stanley, MD Massachusetts General Hospital
  • Takara Stanley, MD Massachusetts General Hospital