Therapy for Children With Advanced Stage Neuroblastoma
Last updated on July 2021Recruitment
- Recruitment Status
- Active, not recruiting
- Estimated Enrollment
- 110
Summary
- Conditions
- Neuroblastoma
- Type
- Interventional
- Phase
- Phase 2
- Design
- Allocation: N/AIntervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Younger than 18 years
- Gender
- Both males and females
Description
The phases of the study are: Screening phase: Tests and evaluations will be done before treatment starts. Induction phase: Includes chemotherapy plus hu14.18K322A mAb. Participants will also have surgery during this part of the study to remove as much tumor as possible. Consolidation/Intensification...
The phases of the study are: Screening phase: Tests and evaluations will be done before treatment starts. Induction phase: Includes chemotherapy plus hu14.18K322A mAb. Participants will also have surgery during this part of the study to remove as much tumor as possible. Consolidation/Intensification phase: Includes high doses of chemotherapy and blood stem cell transplantation with additional, experimental "minimal residual disease" (MRD) treatment. Participants will also get radiation treatment to all sites of the tumor(s) after recovery from the stem cell transplant. Maintenance/MRD treatment phase: With immune therapy in addition to the standard treatment with the drug isotretinoin.
Tracking Information
- NCT #
- NCT01857934
- Collaborators
- Cookies for Kids' Cancer
- CURE Childhood Cancer, Inc.
- Investigators
- Principal Investigator: Wayne L. Furman, MD St. Jude Children's Research Hospital
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