Recruitment

Recruitment Status
Completed
Estimated Enrollment
140

Inclusion Criteria

Written informed consent
Both genders and all ethnic origins, age between 18 and 45
Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse), as assessed by subject history and a structured clinical interview (SCID-I/NP)
...
Written informed consent
Both genders and all ethnic origins, age between 18 and 45
Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse), as assessed by subject history and a structured clinical interview (SCID-I/NP)
Absence of pregnancy as determined by completion of a negative urine pregnancy test prior to the MRI scan
Fluent English speaker
Absence of any medications for at least 3 weeks
Absence of current drug use (cocaine, cannabinoids, opiates, amphetamines, methamphetamines, phencyclidine, MDMA, benzodiazepines, methadone, oxycodone, tricyclic antidepressants, and barbiturates) as assessed by a urine drug test.
Right-handed

Exclusion Criteria

History or current diagnosis of dementia
Evidence of significant inconsistencies in self-report.
Clinical or laboratory evidence of hypothyroidism
...
History or current diagnosis of dementia
Evidence of significant inconsistencies in self-report.
Clinical or laboratory evidence of hypothyroidism
History of seizure disorder
History of head injury
History or current diagnosis of any DSM-IV psychiatric illnesses; Presence of a DSM-IV psychiatric illness within a first-degree relative
Current use of any drug or herbal supplement with well-characterized psychotropic effects (e.g. St. John's wort)
Failure to meet standard fMRI safety requirements
Currently taking medication that affects blood flow, e.g. certain blood pressure medications
Pregnant or currently breast-feeding women or any woman of childbearing potential who is seeking to become pregnant or suspects that she may be pregnant.
History or current use of any psychiatric medication
History or current serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease
Patients with mood congruent or mood incongruent psychotic features
History of use of dopaminergic drugs (including methylphenidate)
Diabetes with poor glucose control
History of cocaine or stimulant use (e.g., amphetamine, cocaine, methamphetamine)

Summary

Conditions
  • Anhedonia
  • Healthy
  • Stress
Type
Observational
Design
  • Observational Model: Cohort
  • Time Perspective: Cross-Sectional

Participation Requirements

Age
Between 18 years and 45 years
Gender
Both males and females

Description

The purpose of this research study is to investigate how the brain processes emotions, and the way these processes affect behavior. Specifically, we hypothesize that individual differences in reward responsiveness will correlate with differential activation in mesolimbic regions of the brain and pre...

The purpose of this research study is to investigate how the brain processes emotions, and the way these processes affect behavior. Specifically, we hypothesize that individual differences in reward responsiveness will correlate with differential activation in mesolimbic regions of the brain and predict future wellbeing in follow-up interviews. Participating in this study involves up to two sessions and up to 7.5 hours. In the present observational study, each participant will be exposed to the same experimental procedure. Visit 1 will take about 4.5 hours, from 12pm to 4:30pm. The visit will take place at the Center for Depression, Anxiety and Stress at McLean. During this visit, a clinical interviewer will conduct a diagnostic SCID interview to ensure that participants qualify to take part in this research study. Participants will then complete several tasks. These tasks include several different "game-like" situations and arithmetic riddles, all of which are simple but require participants to work hard and remain alert for an extended period of time. The goal during these games is to earn as much money as you can or to avoid losing money. Participants will do so by responding (pressing a keyboard button) quickly and accurately. These tasks are intended as assessment tools, and are not a form of therapy or intervention. In addition, we will test participants' ability to keep their hand in cold water. Participants will also be asked to provide blood (via a saline IV) and saliva samples at different times during this session, and we will also conduct urine drug and pregnancy tests. The IV will be in place for a total of around 3 hours, and is used to reduce discomfort from multiple blood draws. Visit 2 will take place at the McLean Imaging Center at McLean Hospital. During the first part of the session, the fMRI scanner will take structural pictures of brain anatomy. Next, additional images will be obtained while participants complete several different "game-like" tasks, similar to the tasks performed in visit 1. Again, these tasks are intended as assessment tools, and are not a form of therapy or intervention. The whole fMRI session will last up to about 2.5 hours; participants will spend about 1.5 hours in the fMRI machine, and about a half-an-hour completing questionnaires and providing saliva samples. Prior to the fMRI scan, another urine sample will be obtained to check for drugs which may interfere with the experiment. After the second study session is complete, participants will be re-contacted through the internet every four weeks for a total of six months, to complete some questionnaires. At the end of six months, participants will be asked to return to McLean to complete an in-person interview. This follow-up period is purely observational and not intended to assess health outcomes, as there is no intervention in this study.

Inclusion Criteria

Written informed consent
Both genders and all ethnic origins, age between 18 and 45
Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse), as assessed by subject history and a structured clinical interview (SCID-I/NP)
...
Written informed consent
Both genders and all ethnic origins, age between 18 and 45
Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse), as assessed by subject history and a structured clinical interview (SCID-I/NP)
Absence of pregnancy as determined by completion of a negative urine pregnancy test prior to the MRI scan
Fluent English speaker
Absence of any medications for at least 3 weeks
Absence of current drug use (cocaine, cannabinoids, opiates, amphetamines, methamphetamines, phencyclidine, MDMA, benzodiazepines, methadone, oxycodone, tricyclic antidepressants, and barbiturates) as assessed by a urine drug test.
Right-handed

Exclusion Criteria

History or current diagnosis of dementia
Evidence of significant inconsistencies in self-report.
Clinical or laboratory evidence of hypothyroidism
...
History or current diagnosis of dementia
Evidence of significant inconsistencies in self-report.
Clinical or laboratory evidence of hypothyroidism
History of seizure disorder
History of head injury
History or current diagnosis of any DSM-IV psychiatric illnesses; Presence of a DSM-IV psychiatric illness within a first-degree relative
Current use of any drug or herbal supplement with well-characterized psychotropic effects (e.g. St. John's wort)
Failure to meet standard fMRI safety requirements
Currently taking medication that affects blood flow, e.g. certain blood pressure medications
Pregnant or currently breast-feeding women or any woman of childbearing potential who is seeking to become pregnant or suspects that she may be pregnant.
History or current use of any psychiatric medication
History or current serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease
Patients with mood congruent or mood incongruent psychotic features
History of use of dopaminergic drugs (including methylphenidate)
Diabetes with poor glucose control
History of cocaine or stimulant use (e.g., amphetamine, cocaine, methamphetamine)

Locations

Belmont, Massachusetts, 02478
Belmont, Massachusetts, 02478

Tracking Information

NCT #
NCT01850472
Collaborators
National Institute of Mental Health (NIMH)
Investigators
  • Principal Investigator: Diego Pizzagalli, PhD Mclean Hospital
  • Diego Pizzagalli, PhD Mclean Hospital