Recruitment

Recruitment Status
Active, not recruiting
Estimated Enrollment
80

Inclusion Criteria

18 years of age or above
New or worsening symptoms- Abnormal coronary angiography or abnormal prior stress imaging study.
Risk Assessment with prior test results and/or previous history of known chronic stable CAD.
...
18 years of age or above
New or worsening symptoms- Abnormal coronary angiography or abnormal prior stress imaging study.
Risk Assessment with prior test results and/or previous history of known chronic stable CAD.
Borderline or discordant stress testing where obstructive CAD remains a concern.
In absence of reliable diagnostic information from another imaging modality.
Acute Chest pain, as per patient input.
Coronary stenosis or anatomic abnormality of uncertain significance.
Patients referred to a stress test by a Cardiologist

Exclusion Criteria

History of type II heparin-induced thrombocytopenia.
Non-dialysis dependent chronic kidney disease with baseline serum creatinine greater than 2.5 gm/dL.
Pregnant women.
...
History of type II heparin-induced thrombocytopenia.
Non-dialysis dependent chronic kidney disease with baseline serum creatinine greater than 2.5 gm/dL.
Pregnant women.
Incapacitated for Consent
Significant co-morbid condition that is medically unstable and would make coronary angiography prohibitive or contraindicated.
Left ventricular ejection fraction less the 25% determined by gated SPECT imaging

Summary

Conditions
  • Coronary (Artery) Disease
  • Coronary Artery Disease
Type
Observational
Design
  • Observational Model: Other
  • Time Perspective: Prospective

Participation Requirements

Age
Between 18 years and 100 years
Gender
Both males and females

Description

Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease. In order to achieve this, two novel parameters, pressure drop coefficient (CDP), which combines flow and pressure readings and Lesion flow coeffi...

Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease. In order to achieve this, two novel parameters, pressure drop coefficient (CDP), which combines flow and pressure readings and Lesion flow coefficient (LFC), which combines anatomical details of the lesion with pressure and flow readings, are being investigated. The diagnostic parameters will be correlated with Coronary Flow Reserve (CFR)values obtained using Positron Emission Tomography (PET) imaging. They will also be correlated with Fractional Flow Reserve (FFR).

Inclusion Criteria

18 years of age or above
New or worsening symptoms- Abnormal coronary angiography or abnormal prior stress imaging study.
Risk Assessment with prior test results and/or previous history of known chronic stable CAD.
...
18 years of age or above
New or worsening symptoms- Abnormal coronary angiography or abnormal prior stress imaging study.
Risk Assessment with prior test results and/or previous history of known chronic stable CAD.
Borderline or discordant stress testing where obstructive CAD remains a concern.
In absence of reliable diagnostic information from another imaging modality.
Acute Chest pain, as per patient input.
Coronary stenosis or anatomic abnormality of uncertain significance.
Patients referred to a stress test by a Cardiologist

Exclusion Criteria

History of type II heparin-induced thrombocytopenia.
Non-dialysis dependent chronic kidney disease with baseline serum creatinine greater than 2.5 gm/dL.
Pregnant women.
...
History of type II heparin-induced thrombocytopenia.
Non-dialysis dependent chronic kidney disease with baseline serum creatinine greater than 2.5 gm/dL.
Pregnant women.
Incapacitated for Consent
Significant co-morbid condition that is medically unstable and would make coronary angiography prohibitive or contraindicated.
Left ventricular ejection fraction less the 25% determined by gated SPECT imaging

Tracking Information

NCT #
NCT01719016
Collaborators
Not Provided
Investigators
  • Principal Investigator: Rupak K Banerjee, PhD University of Cincinnati , CVAMC Principal Investigator: Mohamed Effat, MD Univesity of Cincinnati, University Hospital Principal Investigator: Imran Arif, MD University of Cincinnati and University Hospital Principal Investigator: Hanan Kerr, MD University of Cincinnati
  • Rupak K Banerjee, PhD University of Cincinnati , CVAMC Principal Investigator: Mohamed Effat, MD Univesity of Cincinnati, University Hospital Principal Investigator: Imran Arif, MD University of Cincinnati and University Hospital Principal Investigator: Hanan Kerr, MD University of Cincinnati
About Us
Innovation
Privacy
Terms
Copyright
Get Well Soon © Copyright 2024