OCT-guided LALAK in Children
Last updated on July 2021Recruitment
- Recruitment Status
- Terminated
- Estimated Enrollment
- 10
Summary
- Conditions
- Corneal Opacity
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Younger than 118 years
- Gender
- Both males and females
Description
There is a great need for lamellar keratectomy in the treatment of congenital opacities because the rejection rate in pediatric PK is 4-5 times higher than in adults. In addition, the intraocular inflammatory reaction in infants often leads to synechiae, glaucoma, and cataract. Because LALAK does no...
There is a great need for lamellar keratectomy in the treatment of congenital opacities because the rejection rate in pediatric PK is 4-5 times higher than in adults. In addition, the intraocular inflammatory reaction in infants often leads to synechiae, glaucoma, and cataract. Because LALAK does not penetrate the eye and preserves the host endothelium, it could reduce the risk of these complications. Keratoplasty must be performed at this early age to prevent amblyopia. In this study, OCT-guided LALAK will be performed in patients whose vision is limited by opacity in the anterior 2/3 of the cornea. The objective is to determine if LALAK will provide an equal or better visual outcome than traditional PK without the associated post-operative complications.
Tracking Information
- NCT #
- NCT01579643
- Collaborators
- National Institutes of Health (NIH)
- National Eye Institute (NEI)
- Investigators
- Principal Investigator: Bibiana Reiser, MD Children's Hospital Los Angeles
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