Investigation of Dysynchrony in Patients With Pulmonary Hypertension
Last updated on April 2022Recruitment
- Recruitment Status
- Recruiting
Inclusion Criteria
- Pulmonary artery mean pressure at rest of 25 mm Hg
- Controls (for phase 2) Patients undergoing transcatheter closure of secundum ASD Patients undergoing echocardiogram and ECG as part of work-up for functional murmur who have normal intracardiac anatomy
- Pulmonary artery mean pressure at rest of 25 mm Hg
- Controls (for phase 2) Patients undergoing transcatheter closure of secundum ASD Patients undergoing echocardiogram and ECG as part of work-up for functional murmur who have normal intracardiac anatomy
Exclusion Criteria
- Reversible cause of pulmonary hypertension
- Age < 5 yrs (for phase 2)
- Reversible cause of pulmonary hypertension
- Age < 5 yrs (for phase 2)
Summary
- Conditions
- Pulmonary Hypertension
- Type
- Observational
- Design
- Observational Model: Case-Control
- Time Perspective: Other
Participation Requirements
- Age
- Between 5 years and 125 years
- Gender
- Both males and females
Description
This is a two part study of ventricular dysynchrony in patients with pulmonary hypertension. The first part is an observational study, reviewing routinely obtained clinical information (such as echocardiograms) to assess whether patients with pulmonary hypertension have electrical or mechanical dysy...
This is a two part study of ventricular dysynchrony in patients with pulmonary hypertension. The first part is an observational study, reviewing routinely obtained clinical information (such as echocardiograms) to assess whether patients with pulmonary hypertension have electrical or mechanical dysynchrony. If so, we will proceed to the second part of the study which will assess whether temporarily pacing the right ventricle, during a clinically indicated catheterization can acutely improve hemodynamics. We will also gather control data for phase 1 from clinically indicated echos and ECG's in patients with ASD's (RV volume load) and in patients who are evaluated for an innocent murmur ( Nl heart). We hope to learn whether patients with pulmonary hypertension, and compromised right ventricles have electrical and mechanical dysnchrony. If this is true, it is theoretically possible that resynchronization (pacing) of the right ventricle could improve hemodynamics, symptoms and long term outcomes.
Inclusion Criteria
- Pulmonary artery mean pressure at rest of 25 mm Hg
- Controls (for phase 2) Patients undergoing transcatheter closure of secundum ASD Patients undergoing echocardiogram and ECG as part of work-up for functional murmur who have normal intracardiac anatomy
- Pulmonary artery mean pressure at rest of 25 mm Hg
- Controls (for phase 2) Patients undergoing transcatheter closure of secundum ASD Patients undergoing echocardiogram and ECG as part of work-up for functional murmur who have normal intracardiac anatomy
Exclusion Criteria
- Reversible cause of pulmonary hypertension
- Age < 5 yrs (for phase 2)
- Reversible cause of pulmonary hypertension
- Age < 5 yrs (for phase 2)
Tracking Information
- NCT #
- NCT01571700
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Jeffrey Feinstein, MD, MPH Stan
- Jeffrey Feinstein, MD, MPH Stan
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