Blood Flow MRI for Monitoring Brain Tumors
Last updated on April 2022Recruitment
- Recruitment Status
- Active, not recruiting
Inclusion Criteria
- diagnosed with or are suspected of having a glioma
- diagnosed with or are suspected of having a glioma
Exclusion Criteria
- Pacemaker
- History of claustrophobia
- Recently implanted vascular clip
- ...
- Pacemaker
- History of claustrophobia
- Recently implanted vascular clip
- MRI incompatible metal implant
- Metal fragment within the eye
Summary
- Conditions
- Brain Tumors
- Type
- Observational
- Design
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Our goals are: To compare the blood flow measured with this technique with measures of tumor blood vessel density in pieces of the tumor surgically removed as a normal part of clinical treatment. This will confirm a relationship between the imaging measurements and the microscopic characteristics of...
Our goals are: To compare the blood flow measured with this technique with measures of tumor blood vessel density in pieces of the tumor surgically removed as a normal part of clinical treatment. This will confirm a relationship between the imaging measurements and the microscopic characteristics of tumors. To compare the blood flow in tumors before therapy with the concentration of choline, an indicator of cell proliferation. This choline concentration can be measured with another MRI technique. This information will demonstrate the relationship between cell proliferation and blood supply and will also determine whether the choline measurement adds additional information that is clinically necessary. To determine the reproducibility of blood flow measurements in tumors. This is necessary to better understand the sensitivity of the technique to changes in flow caused by a treatment or changes in tumor vascularity. To monitor changes in blood flow after initial treatment. Since sometimes tumors can reappear, the repeated measures will help determine how useful this new imaging technique is at detecting such recurring tumors.
Inclusion Criteria
- diagnosed with or are suspected of having a glioma
- diagnosed with or are suspected of having a glioma
Exclusion Criteria
- Pacemaker
- History of claustrophobia
- Recently implanted vascular clip
- ...
- Pacemaker
- History of claustrophobia
- Recently implanted vascular clip
- MRI incompatible metal implant
- Metal fragment within the eye
Tracking Information
- NCT #
- NCT01538264
- Collaborators
- National Cancer Institute (NCI)
- Investigators
- Principal Investigator: David C Alsop, PhD Beth Israel Deaconess Medical Center
- David C Alsop, PhD Beth Israel Deaconess Medical Center