Studying Biomarkers in Samples From Patients With High-Risk Neuroblastoma
Last updated on July 2021Recruitment
- Recruitment Status
- Completed
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Neuroblastoma
- Type
- Observational
- Design
- Observational Model: CohortTime Perspective: Retrospective
Participation Requirements
- Age
- Younger than 30 years
- Gender
- Both males and females
Description
OBJECTIVES: To establish telomere length measurement by quantitative polymerase chain reaction (qPCR) as an alternative lengthening of telomeres (ALT) detection method in neuroblastoma (NB). To determine the frequency of ALT in high-risk NB and the characteristics of ALT+ NB. To establish C-circle (...
OBJECTIVES: To establish telomere length measurement by quantitative polymerase chain reaction (qPCR) as an alternative lengthening of telomeres (ALT) detection method in neuroblastoma (NB). To determine the frequency of ALT in high-risk NB and the characteristics of ALT+ NB. To establish C-circle (extra-chromosomal telomeric DNA circles) level as a marker of ALT activity in NB. To evaluate the prognostic significance of ALT in NB. To evaluate the utility of the C-circle assay for the detection of circulating tumor DNA in NB patients with an ALT+ tumor. OUTLINE: Archived tumor tissue and serum samples are analyzed for telomere length measurement, frequency, and C-circle levels by PCR. Results are then compared with patients' age at diagnosis and outcomes including survival data (event-free and overall survival).
Tracking Information
- NCT #
- NCT01510600
- Collaborators
- National Cancer Institute (NCI)
- Investigators
- Principal Investigator: Loretta Lau, MD Sydney Children's Hospitals Network
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