Mesenchymal Stem Cell Transplantation in Osteoarthritis of Hip Joint
Last updated on July 2021Recruitment
- Recruitment Status
- Completed
Summary
- Conditions
- Hip Osteoarthritis
- Type
- Interventional
- Phase
- Phase 1
- Design
- Allocation: N/AIntervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 65 years
- Gender
- Both males and females
Description
This is a phase one clinical study designed to investigate the safety of intra-articular injection of cultured autologous BM-MSCs in patients with severe hip osteoarthritis candidate for total hip replacement. All subjects will undergo bone marrow aspiration. Autologous MSCs will be extracted and cu...
This is a phase one clinical study designed to investigate the safety of intra-articular injection of cultured autologous BM-MSCs in patients with severe hip osteoarthritis candidate for total hip replacement. All subjects will undergo bone marrow aspiration. Autologous MSCs will be extracted and cultured for 4 weeks. Patients will receive intra-articular injection of cultured MSCs under the guide of fluoroscopy. Paraclinical studies (X-Ray and MRI) will be done before and 6 months after treatment. Pain relief and functional improvement of the joint will be assessed by VAS, WOMAC, and Harris Hip Score questionnaire before treatment, and 2 and 6 months after treatment.
Tracking Information
- NCT #
- NCT01499056
- Collaborators
- Not Provided
- Investigators
- Study Chair: Hamid Gourabi, PhD Head of Royan Institute Study Director: Nasser Aghdami, MD,PhD Head of Royan Cell therapy Center Principal Investigator: Mohsen Emadeddin, MD scientist
Get Well Soon