Recruitment

Recruitment Status
Completed
Estimated Enrollment
Same as current

Summary

Conditions
  • Lymphoma
  • Nonneoplastic Condition
Type
Observational
Design
Observational Model: CohortTime Perspective: Retrospective

Participation Requirements

Age
Younger than 9 years
Gender
Both males and females

Description

OBJECTIVES: Evaluate germline DNA from patients with Epstein-Barr virus positive (EBV+) and Hodgkin lymphoma (HL) for inducible T-cell kinase (ITK) mutations. Examine the effects of ITK mutations on expression of the ITK protein. Determine whether ITK mutations correlate with specific clinical or hi...

OBJECTIVES: Evaluate germline DNA from patients with Epstein-Barr virus positive (EBV+) and Hodgkin lymphoma (HL) for inducible T-cell kinase (ITK) mutations. Examine the effects of ITK mutations on expression of the ITK protein. Determine whether ITK mutations correlate with specific clinical or histopathological features of HL. OUTLINE: Archived blood and tumor tissue samples are analyzed for germline DNA expression and inducible T-cell kinase (ITK) mutations by PCR, IHC, flow cytometry, and western blotting, and EBV-encoded RNA (EBER) using in situ hybridization. Each patient's data, such as date, sex, age, tumor stage and histology at diagnosis, treatment received, response to treatment, development of recurrent disease, date of last follow-up, and outcomes are also collected.

Tracking Information

NCT #
NCT01490801
Collaborators
National Cancer Institute (NCI)
Investigators
Principal Investigator: Kim E. Nichols, MD, BA Children's Hospital of Philadelphia