Evaluation of Fructose Ingestion and the Renin Angiotensin System in Humans
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- 30
Summary
- Conditions
- Chronic Kidney Disease
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Crossover AssignmentMasking: Triple (Participant, Investigator, Outcomes Assessor)Primary Purpose: Other
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
PRIMARY AIM: To examine whether the physiologic and molecular responses to Angiotensin II (AngII) challenge differ in response to fructose intake as assessed by two independent means: The renal and mean arterial pressure (MAP) response to an AngII challenge. Reactive changes in circulating levels of...
PRIMARY AIM: To examine whether the physiologic and molecular responses to Angiotensin II (AngII) challenge differ in response to fructose intake as assessed by two independent means: The renal and mean arterial pressure (MAP) response to an AngII challenge. Reactive changes in circulating levels of renin and aldosterone with graded AngII challenge. PRIMARY HYPOTHESES: Ingestion of fructose in healthy subjects will result in: A decrease in renal and systemic sensitivity to infused AngII. A decrease in the reactive changes in renin and aldosterone with graded AngII challenge.
Tracking Information
- NCT #
- NCT01407627
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Sofia B Ahmed, MD MMSc University of Calgary
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