Recruitment

Recruitment Status
Active, not recruiting
Estimated Enrollment
3260

Inclusion Criteria

The interval between the last surgery for breast cancer (treatment or staging) and randomization must be no more than 84 days
For patients who undergo mastectomy, margins must be free of gross residual tumor; (patients with microscopic positive margins are eligible as long as post-mastectomy radiation therapy [RT] of the chest wall will be administered)
Eastern Cooperation Oncology Group (ECOG) performance status of 0 or 1
...
The interval between the last surgery for breast cancer (treatment or staging) and randomization must be no more than 84 days
For patients who undergo mastectomy, margins must be free of gross residual tumor; (patients with microscopic positive margins are eligible as long as post-mastectomy radiation therapy [RT] of the chest wall will be administered)
Eastern Cooperation Oncology Group (ECOG) performance status of 0 or 1
Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (computed tomography [CT], magnetic resonance imaging [MRI], positron emission tomography [PET]-CT, or PET scan) performed within 90 days prior to randomization does not demonstrate metastatic disease and the above requirements are met
Alkaline phosphatase and AST may not both be > the ULN
pT3 regardless of hormone receptor status, histologic grade, and Oncotype DX Recurrence Score
The patient must have undergone either a total mastectomy or breast-conserving surgery (lumpectomy); (patients who have had a nipple-sparing mastectomy are eligible)
The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
Note: If the IHC staining intensity is reported as a range, e.g., 0 to 1+ or 1+ to 2+, the higher intensity score in the range should be used to determine eligibility
If pathologic nodal staging based on sentinel lymphadenectomy is pN0 or pN1b
Hemoglobin must be >= 10 g/dL
Total bilirubin must be =< upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert disease or similar syndrome involving slow conjugation of bilirubin
The patient must have ER analysis performed on the primary tumor prior to randomization; if ER analysis is negative, then PgR analysis must also be performed (either the core biopsy or surgical resection specimen can be used for ER/PgR testing); patients with a primary tumor that is hormone receptor-positive or receptor-negative are eligible
pT2 and estrogen receptor (ER) negative and progesterone receptor (PgR) negative; or
Aspartate aminotransferase (AST) must be =< 1.5 x ULN for the lab (if alanine aminotransferase [ALT] is performed instead of AST [per institution's standard practice], the alanine aminotransferase [ALT] value must be =< 1.5 x ULN; if both were performed, the AST must be =< 1.5 x ULN)
pT2 and ER positive (PgR status may be positive or negative) and either grade 3 histology or Oncotype DX Recurrence Score of >= 25; or
Alkaline phosphatase must be =< 2.5 x ULN for the lab
If ISH testing is performed, test results must be as follows and IHC must be 1+ or 2+: the ratio of HER2 to chromosome enumeration probe 17 (CEP17) must be < 2.0 or, if a ratio was not performed, the HER2 gene copy number must be < 4 per nucleus
Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive; or
IHC must be performed and the IHC staining results must indicate a score of 1+ (in situ hybridization [ISH] testing is not required) or 2+ (ISH must also be performed and must indicate that the tumor is HER2-low as described below)
Patients with alkaline phosphatase that is > ULN but =< 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 90 days prior to randomization does not demonstrate metastatic disease
By pathologic evaluation, primary tumor must be pT1-3
For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and ductal carcinoma in situ (DCIS) as determined by the local pathologist; if pathologic examination demonstrates tumor at the line of resection, additional operative procedures may be performed to obtain clear margins; if tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible; (patients with margins positive for lobular carcinoma in situ [LCIS] are eligible without additional resection)
Absolute neutrophil count (ANC) must be >= 1,200/mm^3
NOTE: Since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment; if the baseline LVEF is > 70%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain
The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination
For patients who will receive the TC chemotherapy regimen, the LVEF must be >= 50% regardless of the cardiac imaging facility's lower limit of normal
For patients who will receive the AC-->WP chemotherapy regimen, the LVEF must be >= 55% regardless of the cardiac imaging facility's lower limit of normal
Axillary lymphadenectomy with or without SN isolation procedures
Platelet count must be >= 100,000/mm^3
Women of reproductive potential must agree to use an effective non-hormonal method of contraception (for example condoms, some intrauterine devices, diaphragms, tubal ligation, vasectomized partner, or abstinence) during therapy and for at least 6 months (Arm 1 patients) and for at least 7 months (Arm 2 patients) after the last dose of study therapy (chemotherapy or trastuzumab)
Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer; (comorbid conditions should be taken into consideration, but not the diagnosis of breast cancer)
Submission of tumor samples from the breast surgery is required for all patients; therefore, the local pathology department policy regarding release of tumor samples must be considered in the screening process; patients whose tumor samples are located in a pathology department that by policy will not submit any samples for research purposes should not be approached for participation in the B-47 trial
If pathologic nodal staging based on sentinel lymphadenectomy is pN1mi or pN1a, the primary tumor must be T1 or T2 by pathologic evaluation and the nodal involvement must be limited to 1 or 2 positive nodes
The most recent postoperative serum creatinine performed within 6 weeks prior to randomization must be =< ULN for the lab

Exclusion Criteria

Conditions that would prohibit administration of corticosteroids
Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up
Poorly controlled diabetes mellitus
...
Conditions that would prohibit administration of corticosteroids
Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up
Poorly controlled diabetes mellitus
Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible)
Pregnancy or lactation at the time of study entry; (Note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
3+ on evaluation of any specimen
Whole-breast RT prior to randomization or partial-breast RT that cannot be completed on or before the date of randomization
Uncontrolled hypertension defined as sustained systolic BP > 150 mm Hg or diastolic BP > 90 mm Hg
Active hepatitis B or hepatitis C with abnormal liver function tests
Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricle (LV) function
Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) >= grade 2, per the Common Terminology Criteria for Adverse Events (CTCAE) version (v)4.0
History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
Any continued use of sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy; patients are eligible if these medications are discontinued prior to randomization
Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements
Chemotherapy or HER2-targeted therapy administered for the currently diagnosed breast cancer prior to randomization
Use of any investigational product within 30 days prior to randomization
Continued endocrine therapy such as raloxifene or tamoxifen (or other selective estrogen receptor modulator [SERM]) or an aromatase inhibitor; patients are eligible if these medications are discontinued prior to randomization
Angina pectoris that requires the current use of anti-anginal medication
Chronic daily treatment with corticosteroids with a dose of >= 10 mg/day methylprednisol one equivalent (excluding inhaled steroids)
Synchronous or previous contralateral invasive breast cancer (patients with synchronous and/or previous contralateral DCIS or LCIS are eligible)
Documented cardiomyopathy
Active infection or chronic infection requiring chronic suppressive antibiotics
NOTE: Chest imaging (mandatory for all patients) and other imaging (if required) must have been performed within 90 days prior to randomization
T4 tumors including inflammatory breast cancer
For patients < 50 years old who will receive AC-->WP: uncontrolled hypertension defined as sustained systolic BP > 150 mm Hg or diastolic BP > 90 mm Hg; patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria
Ventricular arrhythmias except for benign premature ventricular contractions
Symptomatic pericarditis
Previous therapy with anthracyclines, taxanes, or trastuzumab for any malignancy
ISH result indicating HER2 gene copy number >= 4 per nucleus on evaluation of any specimen
0 on all evaluations of specimens
ISH with a ratio of HER2 to CEP17 >= 2.0 on evaluation of any specimen
Intrinsic lung disease resulting in dyspnea
Conduction abnormality requiring a pacemaker
Controlled hypertension (systolic BP =< 150 mm Hg and diastolic BP =< 90 mmHg), if anti-hypertensive medication(s) are needed
Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication
NOTE: Patients who are not eligible based on the AC-WP regimen BP criteria but who meet the TC regimen BP criteria are eligible for B-47, if the intended chemotherapy regimen is changed to TC
For patients who will receive TC (regardless of the patient's age): uncontrolled hypertension defined as sustained systolic blood pressure (BP) > 150 mm Hg or diastolic BP > 90 mm Hg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)
Valvular disease with documented compromise in cardiac function
Known hypersensitivity to any of the study drugs or excipients, e.g., polysorbate 80 and Cremophor EL
History of documented congestive heart failure (CHF)

Summary

Conditions
  • HER2/Neu Positive
  • Progesterone Receptor Positive
  • Recurrent Breast Carcinoma
  • Stage IA Breast Cancer AJCC v7
  • Stage IB Breast Cancer AJCC v7
  • Stage IIA Breast Cancer AJCC v6 and v7
  • Stage IIB Breast Cancer AJCC v6 and v7
  • Stage IIIA Breast Cancer AJCC v7
  • Stage IIIC Breast Cancer AJCC v7
Type
Interventional
Phase
Phase 3
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 18 years and 125 years
Gender
Only females

Description

PRIMARY OBJECTIVES: I. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves invasive disease-free survival (IDFS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as human epidermal growth factor receptor (HER)2-low by...

PRIMARY OBJECTIVES: I. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves invasive disease-free survival (IDFS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as human epidermal growth factor receptor (HER)2-low by all HER2 testing performed. SECONDARY OBJECTIVES: I. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves disease-free survival (DFS)-ductal carcinoma in situ (DCIS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed. II. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves breast cancer-free survival (BCFS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed. III. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves recurrence-free interval (RFI) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed. IV. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves distant recurrence-free interval (DRFI) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed. V. To determine whether the addition of trastuzumab to chemotherapy (TC or AC→WP) improves overall survival (OS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed. VI. To evaluate the associations between amenorrhea and circulating reproductive hormone levels, and the associations between chemotherapy regimen, amenorrhea, and IDFS benefit in premenopausal women eligible at baseline for the menstrual history assessments. VII. To evaluate the toxicity associated with each of the regimens. VIII. To test the hypothesis that the HER2 messenger ribonucleic acid (mRNA) level is the predictor of the degree of benefit from trastuzumab and the threshold for benefit in the adjuvant setting is lower than defined by current American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) Guidelines for HER2 assays (immunohistochemistry [IHC] and fluorescent in situ hybridization [FISH]). IX. To identify and/or validate molecular predictors of the degree of benefit from the addition of trastuzumab to chemotherapy (TC or AC→WP). X. To test the alternative hypothesis that the main determinant of trastuzumab response in the adjuvant setting of HER2-low breast cancer is through antibody-dependent cellular cytotoxicity (ADCC) by demonstrating that the polymorphism of the Fcgamma receptor gene is predictive of the degree of benefit from the addition of trastuzumab to chemotherapy (TC or AC→WP). XI. To examine the relationship between behavioral host factors (obesity, tobacco, alcohol) and comorbid conditions that may influence systemic inflammation and breast cancer outcomes, controlling for tumor/stage characteristics and treatment assignment. XII. To examine the relationship between medication exposures that may influence systemic inflammation and breast cancer outcomes, controlling for tumor/stage characteristics and treatment assignment. XIII. To examine the relationship between comorbid conditions, medication exposures, and behavioral host factors together and breast cancer outcomes, controlling for tumor/stage characteristics and treatment assignment. OUTLINE: Patients are randomized to 1 of 2 treatment arms. NOTE: *Chemotherapy regimen is based on the investigator's preference. ARM I: GROUP IA: Patients receive docetaxel intravenously (IV) over 60 minutes and cyclophosphamide IV over 30 minutes on day 1. Treatment repeats every 3 weeks for 6 cycles in the absence of disease progression or unacceptable toxicity. GROUP IB: Patients receive doxorubicin hydrochloride IV over 15 minutes and cyclophosphamide IV over 30 minutes on day 1. Treatment repeats every 2 or 3 weeks for 4 cycles in the absence of disease progression or unacceptable toxicity. Beginning 2-3 weeks after last dose of doxorubicin hydrochloride and cyclophosphamide, patients also receive paclitaxel IV over 60 minutes once weekly for 12 doses in the absence of disease progression or unacceptable toxicity. ARM II: GROUP IIA: Patients receive docetaxel and cyclophosphamide as in Group IA. Patients also receive trastuzumab IV over 30-90 minutes on day 1. Courses repeat every 3 weeks for 1 year in the absence of disease progression or unacceptable toxicity. GROUP IIB: Patients receive doxorubicin hydrochloride, cyclophosphamide, and paclitaxel as in Group IB. Patients also receive trastuzumab IV over 30-90 minutes weekly for 12 doses and then every 3 weeks for subsequent doses. Treatment repeats every 3 weeks for 1 year in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 6 months for 5 years and then every 12 months for 5 years.

Inclusion Criteria

The interval between the last surgery for breast cancer (treatment or staging) and randomization must be no more than 84 days
For patients who undergo mastectomy, margins must be free of gross residual tumor; (patients with microscopic positive margins are eligible as long as post-mastectomy radiation therapy [RT] of the chest wall will be administered)
Eastern Cooperation Oncology Group (ECOG) performance status of 0 or 1
...
The interval between the last surgery for breast cancer (treatment or staging) and randomization must be no more than 84 days
For patients who undergo mastectomy, margins must be free of gross residual tumor; (patients with microscopic positive margins are eligible as long as post-mastectomy radiation therapy [RT] of the chest wall will be administered)
Eastern Cooperation Oncology Group (ECOG) performance status of 0 or 1
Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (computed tomography [CT], magnetic resonance imaging [MRI], positron emission tomography [PET]-CT, or PET scan) performed within 90 days prior to randomization does not demonstrate metastatic disease and the above requirements are met
Alkaline phosphatase and AST may not both be > the ULN
pT3 regardless of hormone receptor status, histologic grade, and Oncotype DX Recurrence Score
The patient must have undergone either a total mastectomy or breast-conserving surgery (lumpectomy); (patients who have had a nipple-sparing mastectomy are eligible)
The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
Note: If the IHC staining intensity is reported as a range, e.g., 0 to 1+ or 1+ to 2+, the higher intensity score in the range should be used to determine eligibility
If pathologic nodal staging based on sentinel lymphadenectomy is pN0 or pN1b
Hemoglobin must be >= 10 g/dL
Total bilirubin must be =< upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert disease or similar syndrome involving slow conjugation of bilirubin
The patient must have ER analysis performed on the primary tumor prior to randomization; if ER analysis is negative, then PgR analysis must also be performed (either the core biopsy or surgical resection specimen can be used for ER/PgR testing); patients with a primary tumor that is hormone receptor-positive or receptor-negative are eligible
pT2 and estrogen receptor (ER) negative and progesterone receptor (PgR) negative; or
Aspartate aminotransferase (AST) must be =< 1.5 x ULN for the lab (if alanine aminotransferase [ALT] is performed instead of AST [per institution's standard practice], the alanine aminotransferase [ALT] value must be =< 1.5 x ULN; if both were performed, the AST must be =< 1.5 x ULN)
pT2 and ER positive (PgR status may be positive or negative) and either grade 3 histology or Oncotype DX Recurrence Score of >= 25; or
Alkaline phosphatase must be =< 2.5 x ULN for the lab
If ISH testing is performed, test results must be as follows and IHC must be 1+ or 2+: the ratio of HER2 to chromosome enumeration probe 17 (CEP17) must be < 2.0 or, if a ratio was not performed, the HER2 gene copy number must be < 4 per nucleus
Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive; or
IHC must be performed and the IHC staining results must indicate a score of 1+ (in situ hybridization [ISH] testing is not required) or 2+ (ISH must also be performed and must indicate that the tumor is HER2-low as described below)
Patients with alkaline phosphatase that is > ULN but =< 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 90 days prior to randomization does not demonstrate metastatic disease
By pathologic evaluation, primary tumor must be pT1-3
For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and ductal carcinoma in situ (DCIS) as determined by the local pathologist; if pathologic examination demonstrates tumor at the line of resection, additional operative procedures may be performed to obtain clear margins; if tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible; (patients with margins positive for lobular carcinoma in situ [LCIS] are eligible without additional resection)
Absolute neutrophil count (ANC) must be >= 1,200/mm^3
NOTE: Since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment; if the baseline LVEF is > 70%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain
The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination
For patients who will receive the TC chemotherapy regimen, the LVEF must be >= 50% regardless of the cardiac imaging facility's lower limit of normal
For patients who will receive the AC-->WP chemotherapy regimen, the LVEF must be >= 55% regardless of the cardiac imaging facility's lower limit of normal
Axillary lymphadenectomy with or without SN isolation procedures
Platelet count must be >= 100,000/mm^3
Women of reproductive potential must agree to use an effective non-hormonal method of contraception (for example condoms, some intrauterine devices, diaphragms, tubal ligation, vasectomized partner, or abstinence) during therapy and for at least 6 months (Arm 1 patients) and for at least 7 months (Arm 2 patients) after the last dose of study therapy (chemotherapy or trastuzumab)
Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer; (comorbid conditions should be taken into consideration, but not the diagnosis of breast cancer)
Submission of tumor samples from the breast surgery is required for all patients; therefore, the local pathology department policy regarding release of tumor samples must be considered in the screening process; patients whose tumor samples are located in a pathology department that by policy will not submit any samples for research purposes should not be approached for participation in the B-47 trial
If pathologic nodal staging based on sentinel lymphadenectomy is pN1mi or pN1a, the primary tumor must be T1 or T2 by pathologic evaluation and the nodal involvement must be limited to 1 or 2 positive nodes
The most recent postoperative serum creatinine performed within 6 weeks prior to randomization must be =< ULN for the lab

Exclusion Criteria

Conditions that would prohibit administration of corticosteroids
Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up
Poorly controlled diabetes mellitus
...
Conditions that would prohibit administration of corticosteroids
Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up
Poorly controlled diabetes mellitus
Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible)
Pregnancy or lactation at the time of study entry; (Note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
3+ on evaluation of any specimen
Whole-breast RT prior to randomization or partial-breast RT that cannot be completed on or before the date of randomization
Uncontrolled hypertension defined as sustained systolic BP > 150 mm Hg or diastolic BP > 90 mm Hg
Active hepatitis B or hepatitis C with abnormal liver function tests
Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricle (LV) function
Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) >= grade 2, per the Common Terminology Criteria for Adverse Events (CTCAE) version (v)4.0
History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
Any continued use of sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy; patients are eligible if these medications are discontinued prior to randomization
Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements
Chemotherapy or HER2-targeted therapy administered for the currently diagnosed breast cancer prior to randomization
Use of any investigational product within 30 days prior to randomization
Continued endocrine therapy such as raloxifene or tamoxifen (or other selective estrogen receptor modulator [SERM]) or an aromatase inhibitor; patients are eligible if these medications are discontinued prior to randomization
Angina pectoris that requires the current use of anti-anginal medication
Chronic daily treatment with corticosteroids with a dose of >= 10 mg/day methylprednisol one equivalent (excluding inhaled steroids)
Synchronous or previous contralateral invasive breast cancer (patients with synchronous and/or previous contralateral DCIS or LCIS are eligible)
Documented cardiomyopathy
Active infection or chronic infection requiring chronic suppressive antibiotics
NOTE: Chest imaging (mandatory for all patients) and other imaging (if required) must have been performed within 90 days prior to randomization
T4 tumors including inflammatory breast cancer
For patients < 50 years old who will receive AC-->WP: uncontrolled hypertension defined as sustained systolic BP > 150 mm Hg or diastolic BP > 90 mm Hg; patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria
Ventricular arrhythmias except for benign premature ventricular contractions
Symptomatic pericarditis
Previous therapy with anthracyclines, taxanes, or trastuzumab for any malignancy
ISH result indicating HER2 gene copy number >= 4 per nucleus on evaluation of any specimen
0 on all evaluations of specimens
ISH with a ratio of HER2 to CEP17 >= 2.0 on evaluation of any specimen
Intrinsic lung disease resulting in dyspnea
Conduction abnormality requiring a pacemaker
Controlled hypertension (systolic BP =< 150 mm Hg and diastolic BP =< 90 mmHg), if anti-hypertensive medication(s) are needed
Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication
NOTE: Patients who are not eligible based on the AC-WP regimen BP criteria but who meet the TC regimen BP criteria are eligible for B-47, if the intended chemotherapy regimen is changed to TC
For patients who will receive TC (regardless of the patient's age): uncontrolled hypertension defined as sustained systolic blood pressure (BP) > 150 mm Hg or diastolic BP > 90 mm Hg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)
Valvular disease with documented compromise in cardiac function
Known hypersensitivity to any of the study drugs or excipients, e.g., polysorbate 80 and Cremophor EL
History of documented congestive heart failure (CHF)

Locations

Ann Arbor, Michigan, 48106
Brewer, Maine, 04412
Oshkosh, Wisconsin, 54904
Lebanon, New Hampshire, 03756
Kirkland, Washington, 98034
...
Ann Arbor, Michigan, 48106
Brewer, Maine, 04412
Oshkosh, Wisconsin, 54904
Lebanon, New Hampshire, 03756
Kirkland, Washington, 98034
Montreal, Quebec, H2X 3E4
Mount Pleasant, Michigan, 48858
Boston, Massachusetts, 02118
Peoria, Illinois, 61615
Wilmington, Ohio, 45177
Eau Claire, Wisconsin, 54701
Farmington Hills, Michigan, 48336
Kearney, Nebraska, 68847
Spruce Pine, North Carolina, 28777
Detroit, Michigan, 48201
Sandusky, Ohio, 44870
Williamsport, Pennsylvania, 17701
Asheville, North Carolina, 28803
Manhattan, Kansas, 66502
La Crosse, Wisconsin, 54601
Auburn, California, 95603
Normal, Illinois, 61761
Charlotte, North Carolina, 28203
Oakland, California, 94602
Sturgeon Bay, Wisconsin, 54235
Urbana, Illinois, 61801
Elmhurst, New York, 11373
Towson, Maryland, 21204
Chattanooga, Tennessee, 37404
Tualatin, Oregon, 97062
East Lansing, Michigan, 48824-7016
Fargo, North Dakota, 58122
Rockford, Illinois, 61114
East Syracuse, New York, 13057
Winston-Salem, North Carolina, 27103
Dodge City, Kansas, 67801
Fort Collins, Colorado, 80524
Asheville, North Carolina, 28806
Boise, Idaho, 83706
Bonne Terre, Missouri, 63628
Atlanta, Georgia, 30303
Raleigh, North Carolina, 27609
Livonia, Michigan, 48154
League City, Texas, 77573
Salt Lake City, Utah, 84143
Boston, Massachusetts, 02111
Ottawa, Illinois, 61350
Pekin, Illinois, 61554
South San Francisco, California, 94080
Centralia, Washington, 98531
San Pablo, California, 94806
Rockford, Illinois, 61108
Las Vegas, Nevada, 89128
Warrensville Heights, Ohio, 44122
Davis, California, 95616
Las Vegas, Nevada, 89148-2405
Denver, Colorado, 80218
Concord, California, 94520
Auburn, Washington, 98001
Amarillo, Texas, 79106
Janesville, Wisconsin, 53548
Cumberland, Maryland, 21502
Wichita, Kansas, 67214
Post Falls, Idaho, 83854
Flint, Michigan, 48503
San Diego, California, 92120
Aurora, Illinois, 60504
Burien, Washington, 98166
Fort Lauderdale, Florida, 33316
Palm Springs, California, 92262
Chicago, Illinois, 60640
Voorhees, New Jersey, 08043
Downers Grove, Illinois, 60515
South Bend, Indiana, 46601
Mequon, Wisconsin, 53097
Mount Clemens, Michigan, 48043
Lancaster, Ohio, 43130
Middleburg Heights, Ohio, 44130
Monroeville, Pennsylvania, 15146
Providence, Rhode Island, 02905
Toledo, Ohio, 43614
Albany, Georgia, 31701
San Rafael, California, 94903
Portland, Oregon, 97227
Las Vegas, Nevada, 89144
Princeton, Illinois, 61356
Cincinnati, Ohio, 45211
Fargo, North Dakota, 58122
Port Huron, Michigan, 48060
Baton Rouge, Louisiana, 70809
Louisville, Kentucky, 40245
Clive, Iowa, 50325
Fayetteville, Georgia, 30214
Drexel Hill, Pennsylvania, 19026
Green Bay, Wisconsin, 54301-3526
Spokane, Washington, 99216
Woodland Hills, California, 91367
Everett, Washington, 98201
Baltimore, Maryland, 21201
Cape Girardeau, Missouri, 63703
Toledo, Ohio, 43617
Pratt, Kansas, 67124
Baltimore, Maryland, 21237
Johnson City, Tennessee, 37604
Anderson, South Carolina, 29621
Springfield, Illinois, 62702
Saint Johnsbury, Vermont, 05819
Clinton Township, Michigan, 48038
Greenbrae, California, 94904
Boulder, Colorado, 80304
Wheeling, West Virginia, 26003
Austin, Texas, 78705
Philadelphia, Pennsylvania, 19107
Cincinnati, Ohio, 45255
Springfield, Missouri, 65804
Robbinsdale, Minnesota, 55422
Pittsburgh, Pennsylvania, 15215
Beverly, Massachusetts, 01915
Denton, Texas, 76201
Charlottesville, Virginia, 22901
Chicago, Illinois, 60625
Rohnert Park, California, 94928
Medford, Oregon, 97504
Mayfield Heights, Ohio, 44124
Jacksonville, Florida, 32207
Weston, Wisconsin, 54476
Duluth, Minnesota, 55805
Detroit, Michigan, 48236
Franklin, North Carolina, 28734
Austin, Texas, 78731
Lima, Ohio, 45804
El Paso, Texas, 79915
Gastonia, North Carolina, 28054
Jonesboro, Arkansas, 72401
Philadelphia, Pennsylvania, 19141
Anderson, South Carolina, 29621
New Hyde Park, New York, 11040
Fridley, Minnesota, 55432
Abilene, Texas, 79601
Sheridan, Wyoming, 82801
Laconia, New Hampshire, 03246
Cincinnati, Ohio, 45219
West Chester, Pennsylvania, 19380
Henderson, North Carolina, 27536
Elkhart, Indiana, 46514
Cleveland, Ohio, 44106
Kansas City, Missouri, 64111
North Platte, Nebraska, 69101
Cork, Co Cork
Jamaica, New York, 11432
Columbus, Ohio, 43215
Beaufort, South Carolina, 29902
Bethesda, Maryland, 20814
Denver, Colorado, 80218
Butler, Pennsylvania, 16001
Longmont, Colorado, 80501
Paoli, Pennsylvania, 19301
Alexandria, Louisiana, 71301
Pueblo, Colorado, 81008
Sullivan, Missouri, 63080
Dearborn, Michigan, 48124
Fargo, North Dakota, 58103
Boston, Massachusetts, 02114
Monmouth, Illinois, 61462
Montreal, Quebec, H3T 1M5
Lansing, Michigan, 48912
Albuquerque, New Mexico, 87106
South Bend, Indiana, 46628
Kingman, Kansas, 67068
Saint George, Utah, 84770
Harvey, Illinois, 60426
Chanute, Kansas, 66720
Roseville, California, 95678
Harbor City, California, 90710
Omaha, Nebraska, 68114
Saint Joseph, Missouri, 64506
Plymouth, Indiana, 46563
Toledo, Ohio, 43623
Kyle, Texas, 78640
Cedar Rapids, Iowa, 52402
Lincoln, Nebraska, 68506
Escanaba, Michigan, 49829
Longmont, Colorado, 80501
Miami Beach, Florida, 33140
Indianapolis, Indiana, 46237
Elk Grove Village, Illinois, 60007
Wisconsin Rapids, Wisconsin, 54494
Naperville, Illinois, 60540
Las Vegas, Nevada, 89148
Brainerd, Minnesota, 56401
Charleston, South Carolina, 29425
Lincoln, Nebraska, 68510
Kernersville, North Carolina, 27284
South Bend, Indiana, 46617
Louisville, Kentucky, 40207
Martinsburg, West Virginia, 25401
Cleveland, Ohio, 44195
Burlingame, California, 94010
Omaha, Nebraska, 68131
Wynnewood, Pennsylvania, 19096
Anderson, Indiana, 46016
Mount Vernon, Washington, 98274
Bellevue, Washington, 98004
Norton, Virginia, 24273
Sheboygan, Wisconsin, 53081
Austin, Texas, 78701
Urbana, Illinois, 61801
Sioux Falls, South Dakota, 57104
Oxnard, California, 93030
Ocala, Florida, 34774
Pocatello, Idaho, 83201
Asheville, North Carolina, 28801
Saint Louis, Missouri, 63131
Rockford, Illinois, 61104
Rock Hill, South Carolina, 29732
Las Vegas, Nevada, 89113
Omaha, Nebraska, 68122
Beaumont, Texas, 77702
Munster, Indiana, 46321
Washington, North Carolina, 27889
River Forest, Illinois, 60305
Las Vegas, Nevada, 89128
Appleton, Wisconsin, 54911
Chicago, Illinois, 60612
Kankakee, Illinois, 60901
Saint Joseph, Missouri, 64507
Spokane, Washington, 99220
San Marcos, Texas, 78666
Minocqua, Wisconsin, 54548
Lapeer, Michigan, 48446
Iron Mountain, Michigan, 49801
Wichita, Kansas, 67208
Prairie Village, Kansas, 66208
Troy, Michigan, 48085
The Woodlands, Texas, 77380
Portland, Oregon, 97213
Grand Forks, North Dakota, 58201
Grand Rapids, Michigan, 49503
Marinette, Wisconsin, 54143
Baltimore, Maryland, 21202
Anchorage, Alaska, 99508
Flower Mound, Texas, 75028
Lawrence, Kansas, 66044
Las Cruces, New Mexico, 88011
Coon Rapids, Minnesota, 55433
Burlington, North Carolina, 27215
Antigo, Wisconsin, 54409
Danville, Pennsylvania, 17822
Durham, North Carolina, 27710
Omaha, Nebraska, 68124
Seattle, Washington, 98101
Denison, Texas, 75020
Mentor, Ohio, 44060
Fishersville, Virginia, 22939
Keene, New Hampshire, 03431
Hudson, New York, 12534
Shepherdsville, Kentucky, 40165
Fort Dodge, Iowa, 50501
Greensboro, North Carolina, 27403
Galveston, Texas, 77555-0565
Green Bay, Wisconsin, 54303
Alton, Illinois, 62002
Roseville, California, 95661
Reidsville, North Carolina, 27320
Madison, Wisconsin, 53717
Lewistown, Pennsylvania, 17044
Dublin, 8
Rice Lake, Wisconsin, 54868
Peoria, Illinois, 61614
Bismarck, North Dakota, 58501
Jefferson City, Missouri, 65109
Brevard, North Carolina, 28712
Saint Joseph, Michigan, 49085
Spokane, Washington, 99202
Berwyn, Illinois, 60402
Tulsa, Oklahoma, 74146
Las Vegas, Nevada, 89128
Burke, Virginia, 22015
Clyde, Ohio, 43410
South Bend, Indiana, 46601
Los Angeles, California, 90034
Tacoma, Washington, 98405
Greenwood, South Carolina, 29646
Pittsburgh, Pennsylvania, 15224
Greenville, South Carolina, 29605
Bloomington, Illinois, 61701
Omaha, Nebraska, 68124
Bristol, Tennessee, 37620
Macomb, Illinois, 61455
Pittsburgh, Pennsylvania, 15212
Chapel Hill, North Carolina, 27599
Oakland, California, 94609
McKeesport, Pennsylvania, 15132
Papillion, Nebraska, 68046
Lancaster, South Carolina, 29720
Canton, Illinois, 61520
Plano, Texas, 75075
Las Vegas, Nevada, 89106
Methuen, Massachusetts, 01844
Madison, Wisconsin, 53792
Wausau, Wisconsin, 54401
Bronx, New York, 10467
Santa Clara, California, 95051
Waterloo, Iowa, 50702
Hazleton, Pennsylvania, 18201
Garland, Texas, 75042
Newark, Ohio, 43055
Havre, Montana, 59501
Normal, Illinois, 61761
Wynnewood, Pennsylvania, 19096
Fond Du Lac, Wisconsin, 54937
Oklahoma City, Oklahoma, 73104
Pittsburgh, Pennsylvania, 15232
Newark, Ohio, 43055
Houston, Texas, 77024
New Britain, Connecticut, 06050
Kansas City, Missouri, 64114
Sunnyvale, California, 94086
Sioux City, Iowa, 51102
Tyler, Texas, 75702
Washington, District of Columbia, 20002
Fairbanks, Alaska, 99701
Salinas, California, 93901
Langhorne, Pennsylvania, 19047
Cambridge, Massachusetts, 02138
Norwich, Connecticut, 06360
Greenville, South Carolina, 29601
Missoula, Montana, 59802
Wilmington, Delaware, 19801
Dayton, Ohio, 45409
Spokane, Washington, 99218
Kewanee, Illinois, 61443
Huntington, West Virginia, 25702
Kalamazoo, Michigan, 49007
Minneapolis, Minnesota, 55407
New York, New York, 10029
Grand Rapids, Michigan, 49503
Columbus, Ohio, 43213
Newark, Delaware, 19713
Twin Falls, Idaho, 83301
Asheville, North Carolina, 28816
Havana, Illinois, 62644
Montreal, Quebec, H3H 2R9
Independence, Ohio, 44131
Chicago, Illinois, 60631
Atlanta, Georgia, 30342
Huntersville, North Carolina, 28078
Canton, Ohio, 44710
Kearney, Nebraska, 68845
Bethlehem, Pennsylvania, 18017
Longview, Texas, 75601
Vacaville, California, 95687
Chicago, Illinois, 60608
Greeley, Colorado, 80631
Seattle, Washington, 98107
Saint Cloud, Minnesota, 56303
Henderson, Nevada, 89074
Cedar Rapids, Iowa, 52403
Shakopee, Minnesota, 55379
Voorhees, New Jersey, 08043
Sequim, Washington, 98384
Portland, Oregon, 97227
Berlin, Vermont, 05602
Dublin, Co Dublin, 24
Paterson, New Jersey, 07503
Walnut Creek, California, 94598
Hattiesburg, Mississippi, 39401
Antioch, California, 94531
Rutherfordton, North Carolina, 28139
West Des Moines, Iowa, 50266-7700
Saint Louis, Missouri, 63141
Asheville, North Carolina, 28801
Columbus, Ohio, 43219
Las Vegas, Nevada, 89144
Pinehurst, North Carolina, 28374
Minot, North Dakota, 58701
Newark, New Jersey, 07101
Portland, Maine, 04101
Jefferson, Iowa, 50129
Gaithersburg, Maryland, 20879
Rock Hill, South Carolina, 29732
Lumberton, North Carolina, 28358
Mount Vernon, Ohio, 43050
Racine, Wisconsin, 53405
Burlington, Wisconsin, 53105
Greenville, South Carolina, 29605
Pittsburgh, Pennsylvania, 15237
Los Angeles, California, 90027
Panorama City, California, 91402
Auburn, California, 95602
Greensburg, Pennsylvania, 15601
Columbus, Ohio, 43222
El Dorado, Kansas, 67042
Elgin, Illinois, 60123
Rancho Mirage, California, 92270
New Orleans, Louisiana, 70121
Gettysburg, Pennsylvania, 17325
Tulsa, Oklahoma, 74136
Phoenix, Arizona, 85016
Independence, Missouri, 64057
Woodbury, Minnesota, 55125
Livingston, New Jersey, 07039
Washington, District of Columbia, 20007
State College, Pennsylvania, 16803
Cincinnati, Ohio, 45230
Savannah, Georgia, 31404
Golden, Colorado, 80401
Wooster, Ohio, 44691
Roseville, California, 95661
Indianapolis, Indiana, 46260
Waterford, Co Waterford, 9
Columbus, Ohio, 43214
Macon, Georgia, 31201
Cincinnati, Ohio, 45242
Cleveland, Ohio, 44109
Grants Pass, Oregon, 97527
Temple, Texas, 76508
Long Beach, California, 90806
Cincinnati, Ohio, 45236
Pontiac, Michigan, 48341
Newark, Delaware, 19713
Saint Cloud, Minnesota, 56303
Atlanta, Georgia, 30342
Sioux Falls, South Dakota, 57105
Huntington, West Virginia, 25701
Bedford, Texas, 76022
Anaheim, California, 92806
Waco, Texas, 76712
Medford, Oregon, 97504
Barberton, Ohio, 44203
Dallas, Texas, 75230
Boston, Massachusetts, 02215
Boiling Springs, South Carolina, 29316
Sheboygan, Wisconsin, 53081
Santa Cruz, California, 95065
Syracuse, New York, 13215
Canton, Illinois, 61520
Providence, Rhode Island, 02906
Williamsburg, Virginia, 23185
Amsterdam, New York, 12010
Lafayette, Colorado, 80026
Silver Spring, Maryland, 20910
Sioux City, Iowa, 51104
Savannah, Georgia, 31405
Scottsdale, Arizona, 85258
Rochester, New York, 14623
Cape Girardeau, Missouri, 63703
Utica, New York, 13502
Parsons, Kansas, 67357
Rapid City, South Dakota, 57701
Jackson, Michigan, 49201
Aurora, Colorado, 80045
Bangor, Maine, 04401
Wadsworth, Ohio, 44281
Kirkland, Washington, 98033
Redwood City, California, 94063
Little Rock, Arkansas, 72205
Oakland, California, 94609
Fargo, North Dakota, 58122
Colorado Springs, Colorado, 80907
Stevens Point, Wisconsin, 54481
Milwaukie, Oregon, 97222
Great Falls, Montana, 59405
Roseville, California, 95661
Cincinnati, Ohio, 45219
Wellington, Kansas, 67152
Warrenville, Illinois, 60555
Wichita, Kansas, 67214
Billings, Montana, 59102
Goldsboro, North Carolina, 27534
Peoria, Illinois, 61637
Rolla, Missouri, 65401
Mobile, Alabama, 36688
Rhinelander, Wisconsin, 54501
Vacaville, California, 95687
Bellflower, California, 90706
Cameron Park, California, 95682
Columbus, Georgia, 31904
Seattle, Washington, 98104
Bismarck, North Dakota, 58501
Two Rivers, Wisconsin, 54241
Honolulu, Hawaii, 96813
Wichita, Kansas, 67208
Sylvania, Ohio, 43560
Bellefontaine, Ohio, 43311
Greer, South Carolina, 29650
Annapolis, Maryland, 21401
Palo Alto, California, 94304
Greer, South Carolina, 29651
Atlanta, Georgia, 30322
Sioux City, Iowa, 51101
Mishawaka, Indiana, 46545
Strongsville, Ohio, 44136
Provo, Utah, 84604
Jacksonville, North Carolina, 28546
Pittsburgh, Pennsylvania, 15213
Oregon City, Oregon, 97045
Bismarck, North Dakota, 58501
Honolulu, Hawaii, 96813
Elmira, New York, 14905
Arroyo Grande, California, 93420
Auburn, New York, 13021
Saginaw, Michigan, 48601
Gloucester, Virginia, 23061
Thomasville, North Carolina, 27360
Parker, Colorado, 80138
West Des Moines, Iowa, 50266
Greenville, Ohio, 45331
Lancaster, Ohio, 43130
Charleston, South Carolina, 29406
Pekin, Illinois, 61554
Newberg, Oregon, 97132
Cedar Rapids, Iowa, 52402
Great Falls, Montana, 59405
Havana, Illinois, 62644
Easton, Maryland, 21601
Savannah, Georgia, 31404
Charlotte, North Carolina, 28207
Indianapolis, Indiana, 46256
Exeter, New Hampshire, 03833
Wisconsin Rapids, Wisconsin, 54494
Mount Vernon, Illinois, 62864
Cheyenne, Wyoming, 82001
Cincinnati, Ohio, 45202
Poulsbo, Washington, 98370
Cincinnati, Ohio, 45247
Fairfield, Ohio, 45014
West Reading, Pennsylvania, 19611
Mooresville, North Carolina, 28117
Ephrata, Pennsylvania, 17522
Baltimore, Maryland, 21229
Thornton, Colorado, 80229
Greenville, South Carolina, 29615
Charleston, South Carolina, 29414
Sayre, Pennsylvania, 18840
Detroit, Michigan, 48202
Mullica Hill, New Jersey, 08062
Concord, New Hampshire, 03301
Elkhart, Indiana, 46515
Fresno, California, 93720
Chicago, Illinois, 60612
Marshfield, Wisconsin, 54449
Santa Ana, California, 92705
Spring Valley, Illinois, 61362
Nampa, Idaho, 83686
Milwaukee, Wisconsin, 53226
Lynchburg, Virginia, 24501
Logan, Utah, 84321
Oakland, California, 94611
Shelby, North Carolina, 28150
Shreveport, Louisiana, 71105
McPherson, Kansas, 67460
Gresham, Oregon, 97030
Marinette, Wisconsin, 54143
Lima, Ohio, 45801
Mishawaka, Indiana, 46545
Enumclaw, Washington, 98022
Zanesville, Ohio, 43701
Bend, Oregon, 97701
Pottstown, Pennsylvania, 19464
Ogden, Utah, 84403
Cooperstown, New York, 13326
Sioux Falls, South Dakota, 57117-5134
Springfield, Illinois, 62781
Buffalo, New York, 14263
Round Rock, Texas, 78681
Rockville, Maryland, 20850
Orlando, Florida, 32803
Springfield, Ohio, 45505
Fond Du Lac, Wisconsin, 54935
Charleston, West Virginia, 25304
Chillicothe, Ohio, 45601
Decatur, Illinois, 62526
Savannah, Georgia, 31405
Elmhurst, Illinois, 60126
Eureka, Illinois, 61530
Pomona, California, 91767
Charleston, South Carolina, 29401
Martinez, California, 94553-3156
Montreal, Quebec, H2W 1T8
Dublin, Co Dublin, 7
Middletown, New York, 10940
Richmond, Indiana, 47374
Clinton, North Carolina, 28328
Albany, New York, 12208
Anchorage, Alaska, 99508
Edmonds, Washington, 98026
Meadowbrook, Pennsylvania, 19046
Sacramento, California, 95823
Washington, District of Columbia, 20016
Spokane, Washington, 99218
Attleboro, Massachusetts, 02703
Monroe, Louisiana, 71202
Kokomo, Indiana, 46904
Walnut Creek, California, 94596
Palo Alto, California, 94301
Elkton, Maryland, 21921
Orlando, Florida, 32822
Des Moines, Iowa, 50314
Independence, Kansas, 67301
Joliet, Illinois, 60435
Kennewick, Washington, 99336
Atlanta, Georgia, 30308
Louisville, Kentucky, 40215
Spokane Valley, Washington, 99216
Baltimore, Maryland, 21244
Rancho Cordova, California, 95670
Monroe, Michigan, 48162
Asheboro, North Carolina, 27203
Lewiston, Idaho, 83501
Dayton, Ohio, 45459
Sligo, Co Sligo
Castro Valley, California, 94546
Summit, Wisconsin, 53066
Honolulu, Hawaii, 96859
Murray, Utah, 84107
Statesville, North Carolina, 28677
Joplin, Missouri, 64804
Galesburg, Illinois, 61401
San Diego, California, 92108
Grand Blanc, Michigan, 48439
Big Rapids, Michigan, 49307
Lewisburg, Pennsylvania, 17837
Las Vegas, Nevada, 89109
Beaver, Pennsylvania, 15009
Baton Rouge, Louisiana, 70809
Eau Claire, Wisconsin, 54701
Somerville, New Jersey, 08876
Maumee, Ohio, 43537
Normal, Illinois, 61761
Honolulu, Hawaii, 96826
York, Maine, 03909
Fredericksburg, Virginia, 22401
Westerville, Ohio, 43081
Carbondale, Illinois, 62902
Oregon, Ohio, 43616
Carthage, Illinois, 62321
Spartanburg, South Carolina, 29303
Glens Falls, New York, 12801
Natrona Heights, Pennsylvania, 15065
Ephrata, Pennsylvania, 17522
Clackamas, Oregon, 97015
Tacoma, Washington, 98405
Grand Rapids, Michigan, 49503
Altamonte Springs, Florida, 32701
Albuquerque, New Mexico, 87110
Denver, Colorado, 80220
Beachwood, Ohio, 44122
Ooltewah, Tennessee, 37363
Fort Scott, Kansas, 66701
Des Moines, Iowa, 50309
Peoria, Illinois, 61615
State College, Pennsylvania, 16801
Franklin, Ohio, 45005-1066
Seattle, Washington, 98112
Nashua, New Hampshire, 03063
Athens, Georgia, 30607
Wichita, Kansas, 67214
Dallas, Texas, 75390
Sacramento, California, 95816
Honolulu, Hawaii, 96813
Beech Grove, Indiana, 46107
Galesburg, Illinois, 61401
Houston, Texas, 77030
Eureka, Illinois, 61530
Mayfield Heights, Ohio, 44124
Clinton, North Carolina, 28328
Troy, Ohio, 45373
Fontana, California, 92335
New York, New York, 10019
Columbus, Ohio, 43228
Tacoma, Washington, 98405
Anchorage, Alaska, 99508
Richmond, Virginia, 23298
Seattle, Washington, 98195
Nashville, Tennessee, 37208
Henderson, Nevada, 89074
Mountain View, California, 94040
Greenville, South Carolina, 29605
Branson, Missouri, 65616
Flint, Michigan, 48532
Niles, Michigan, 49120
Chicago, Illinois, 60612
Tulsa, Oklahoma, 74136
Elizabethtown, Kentucky, 42701
Reed City, Michigan, 49677
New Richmond, Wisconsin, 54017
Las Vegas, Nevada, 89121
Charlotte, North Carolina, 28204
Plano, Texas, 75093
Gloucester, Massachusetts, 01930
Sacramento, California, 95823
Lake Success, New York, 11042
Baltimore, Maryland, 21287
Rocky Mount, North Carolina, 27804
Mountain View, California, 94040
Modesto, California, 95356
Stockton, California, 95210
Las Vegas, Nevada, 89148
Green Bay, Wisconsin, 54303
Orlando, Florida, 32806
Englewood, Colorado, 80113
Rochester, New York, 14642
Monroe, Michigan, 48162
Fergus Falls, Minnesota, 56537
Wauseon, Ohio, 43567
Grand Junction, Colorado, 81501
Omaha, Nebraska, 68130
Brooklyn, New York, 11235
Sioux Falls, South Dakota, 57105
Maumee, Ohio, 43537
Columbus, Ohio, 43214
Quebec City, Quebec, G1S 4L8
Augusta, Maine, 04330
Kansas City, Missouri, 64132
Springfield, Missouri, 65807
Rhinelander, Wisconsin, 54501
Riverdale, Georgia, 30274
Limerick, Co Limerick, 9
Waterford, Connecticut, 06385
Walla Walla, Washington, 99362
Wenatchee, Washington, 98801
American Fork, Utah, 84003
Orange Park, Florida, 32073
Pueblo, Colorado, 81004
Green Bay, Wisconsin, 54301
Lexington, Kentucky, 40536
Pleasanton, California, 94588
Lawton, Oklahoma, 73505
Lake Success, New York, 11042
Dublin, Co Dublin, 7
Philadelphia, Pennsylvania, 19140
Lincoln, Nebraska, 68516
Kalispell, Montana, 59901
Philadelphia, Pennsylvania, 19143
Hattiesburg, Mississippi, 39404
Lexington, Kentucky, 40504
Hendersonville, North Carolina, 28791
Marshalltown, Iowa, 50158
Fort Wayne, Indiana, 46845
Lexington, Kentucky, 40503
'Aiea, Hawaii, 96701
Geneva, Illinois, 60134
Lewisville, Texas, 75067
Boulder, Colorado, 80301
San Francisco, California, 94115
Portland, Oregon, 97225
Joplin, Missouri, 64804
Camden, New Jersey, 08103
Glendale, California, 91204
Las Vegas, Nevada, 89109
Huntersville, North Carolina, 28078
Baltimore, Maryland, 21201
Lone Tree, Colorado, 80124
Hagerstown, Maryland, 21742
Bay City, Michigan, 48706
Providence, Rhode Island, 02903
Gainesville, Florida, 32610
Ann Arbor, Michigan, 48109
Ames, Iowa, 50010
Mount Vernon, Washington, 98274
Newark, Delaware, 19713
Corbin, Kentucky, 40701
South Weymouth, Massachusetts, 02190
Willmar, Minnesota, 56201
Winston-Salem, North Carolina, 27103
Dayton, Ohio, 45405
Bennington, Vermont, 05201
Mansfield, Ohio, 44903
Portsmouth, Ohio, 45662
Pittsburgh, Pennsylvania, 15232
Des Moines, Iowa, 50314
Lowell, Massachusetts, 01854
Kingsport, Tennessee, 37660
Lansing, Michigan, 48910
Seattle, Washington, 98104
Winter Park, Florida, 32792
Cleveland, Ohio, 44111
Denver, Colorado, 80222
Peru, Illinois, 61354
Oklahoma City, Oklahoma, 73109
Medford, Oregon, 97504
Liberal, Kansas, 67905
Bowling Green, Ohio, 43402
Marshfield, Wisconsin, 54449
Decatur, Illinois, 62526
Goldsboro, North Carolina, 27534
Vallejo, California, 94589
Anacortes, Washington, 98221
Reading, Pennsylvania, 19605
Toledo, Ohio, 43623
Pittsfield, Massachusetts, 01201
Raleigh, North Carolina, 27614
Centerville, Ohio, 45459
Duluth, Minnesota, 55805
Bridgeport, West Virginia, 26330
Puyallup, Washington, 98372
Oregon, Ohio, 43616
Easton, Pennsylvania, 18042
Lakewood, Colorado, 80228
Fremont, California, 94538
Frederick, Maryland, 21701
Tacoma, Washington, 98405
Poughkeepsie, New York, 12601
Saint Paul, Minnesota, 55101
Baltimore, Maryland, 21204
New Orleans, Louisiana, 70112
Harrisburg, Pennsylvania, 17109
Austin, Texas, 78758
Saint Louis Park, Minnesota, 55416
Saint Paul, Minnesota, 55102
Manhasset, New York, 11030
Federal Way, Washington, 98003
Chesterfield, Missouri, 63017
Newton, Massachusetts, 02462
Burbank, California, 91505
Meridian, Idaho, 83642
Lone Tree, Colorado, 80124
Riverside, California, 92505
Loveland, Colorado, 80539
White Plains, New York, 10601
Hixson, Tennessee, 37343
Vancouver, Washington, 98684
Wright-Patterson Air Force Base, Ohio, 45433
Steubenville, Ohio, 43952
Burnsville, Minnesota, 55337
Seattle, Washington, 98109
Flint, Michigan, 48532
Meriden, Connecticut, 06451
Seattle, Washington, 98104
Mount Kisco, New York, 10549-3417
Weston, Wisconsin, 54476
Scranton, Pennsylvania, 18510
Topeka, Kansas, 66606
Burlington, Massachusetts, 01805
Media, Pennsylvania, 19063
Michigan City, Indiana, 46360
Toledo, Ohio, 43606
Scarborough, Maine, 04074
Durango, Colorado, 81301
Poughkeepsie, New York, 12601
Duluth, Minnesota, 55805
Statesville, North Carolina, 28625
Montreal, Quebec, H2L 4M1
Minneapolis, Minnesota, 55415
Baldwin Park, California, 91706
Maumee, Ohio, 43537
Chardon, Ohio, 44024
Waconia, Minnesota, 55387
Macomb, Illinois, 61455
Akron, Ohio, 44304
Cincinnati, Ohio, 45220
Las Vegas, Nevada, 89119
Winston-Salem, North Carolina, 27103
Lone Tree, Colorado, 80124
Las Vegas, Nevada, 89128
Issaquah, Washington, 98029
Danvers, Massachusetts, 01923
Denver, Colorado, 80205
Berkeley, California, 94704
Daytona Beach, Florida, 32114
Danville, Illinois, 61832
Ann Arbor, Michigan, 48106
Des Moines, Iowa, 50309
Sellersville, Pennsylvania, 18960
Honolulu, Hawaii, 96817
Pittsburgh, Pennsylvania, 15243
Norristown, Pennsylvania, 19401
Gastonia, North Carolina, 28054
Laurinburg, North Carolina, 28352
Tacoma, Washington, 98405
Hutchinson, Minnesota, 55350
Rehoboth Beach, Delaware, 19971
Fall River, Massachusetts, 02721
Darby, Pennsylvania, 19023-1291
Saint Louis, Missouri, 63141
Denver, Colorado, 80220
Clarkston, Michigan, 48346
Southfield, Michigan, 48075
Muncie, Indiana, 47303
Santa Rosa, California, 95403
Saint Louis, Missouri, 63110
Kalispell, Montana, 59901
Princeton, West Virginia, 24740
New Orleans, Louisiana, 70112
Lakeland, Florida, 33805
Overland Park, Kansas, 66209
Yorkville, Illinois, 60560
Anchorage, Alaska, 99508
Sacramento, California, 95825
Bryn Mawr, Pennsylvania, 19010
Smithfield, North Carolina, 27577
Oconomowoc, Wisconsin, 53066
Saint Louis, Missouri, 63141
Newark, Delaware, 19718
Hendersonville, North Carolina, 28791
Emeryville, California, 94608
Fort Lauderdale, Florida, 33308
Manchester, New Hampshire, 03103
Ottawa, Illinois, 61350
Stony Brook, New York, 11794
Jonesboro, Arkansas, 72401
Ottumwa, Iowa, 52501
Louisville, Kentucky, 40202
Warren, Michigan, 48093
Missoula, Montana, 59802
Jackson, Mississippi, 39216
Las Vegas, Nevada, 89169
Peru, Illinois, 61354
Rockport, Maine, 04856
Shelby, North Carolina, 28150
Oak Lawn, Illinois, 60453-2699
Centralia, Illinois, 62801
Randallstown, Maryland, 21133
Fayetteville, North Carolina, 28304
Bardstown, Kentucky, 40004
Kansas City, Missouri, 64116
Saint Joseph, Michigan, 49085
East Stroudsburg, Pennsylvania, 18301
Lexington, Kentucky, 40509
Marietta, Ohio, 45750
Wausau, Wisconsin, 54401
Elkhart, Indiana, 46514-2098
Toms River, New Jersey, 08755
Evanston, Illinois, 60202
Moon, Pennsylvania, 15108
Cork
Pascagoula, Mississippi, 39581
Bellevue, Washington, 98004
Oklahoma City, Oklahoma, 73142
Calgary, Alberta, T2N 4N2
Milwaukee, Wisconsin, 53210
Billings, Montana, 59102
Cedar Park, Texas, 78613
Mount Holly, New Jersey, 08060
Peoria, Illinois, 61636
Laredo, Texas, 78041
Indianapolis, Indiana, 46219
Kalispell, Montana, 59901
Albuquerque, New Mexico, 87102
Ames, Iowa, 50010
Miami, Florida, 33136
Concord, North Carolina, 28025
Vancouver, Washington, 98686
Saint Louis, Missouri, 63136
Galway, Co Galway
DuBois, Pennsylvania, 15801
Rolla, Missouri, 65401
Denver, Colorado, 80218
Winston-Salem, North Carolina, 27104
Pittsburgh, Pennsylvania, 15236
Elyria, Ohio, 44035
Metairie, Louisiana, 70006
Henderson, Nevada, 89052
Omaha, Nebraska, 68130
Uniontown, Pennsylvania, 15401
Las Vegas, Nevada, 89148
Oxford, North Carolina, 27565
Omaha, Nebraska, 68198
Orlando, Florida, 32803
Marietta, Georgia, 30060
Saint Louis Park, Minnesota, 55416
Vineland, New Jersey, 08360
Green Bay, Wisconsin, 54311
Wilkesboro, North Carolina, 28659
San Antonio, Texas, 78229
San Marcos, California, 92078
Westlake, Ohio, 44145
East Norriton, Pennsylvania, 19403
Morristown, New Jersey, 07960
Virginia Beach, Virginia, 23454
Vancouver, Washington, 98664
Las Vegas, Nevada, 89102
Novato, California, 94945
Fairhaven, Massachusetts, 02719
Framingham, Massachusetts, 01702
Elyria, Ohio, 44035
Pittsburgh, Pennsylvania, 15213
Middletown, Connecticut, 06457
Newark, Delaware, 19713
Monroe, North Carolina, 28112
Abington, Pennsylvania, 19001
Matthews, North Carolina, 28105
Spokane, Washington, 99204
Seneca, South Carolina, 29672
Mebane, North Carolina, 27302
Charlotte, North Carolina, 28262
Hershey, Pennsylvania, 17033-0850
Newton, Kansas, 67114
Aberdeen, South Dakota, 57401
Modesto, California, 95355
Denver, Colorado, 80218
Adrian, Michigan, 49221
Ottawa, Illinois, 61350
Portland, Oregon, 97210
Delaware, Ohio, 43015
Stillwater, Minnesota, 55082
Omaha, Nebraska, 68106
Longview, Washington, 98632
Gulfport, Mississippi, 39502
Fairfax, Virginia, 22033
Irvine, California, 92618
Liberty, Missouri, 64068
Castro Valley, California, 94546
Findlay, Ohio, 45840
New York, New York, 10032
Monterey, California, 93940
Saint Helena, California, 94574
Billings, Montana, 59101
Allentown, Pennsylvania, 18103
Montreal, Quebec, H3G 1A4
Hampton, Virginia, 23666
Summit, New Jersey, 07902
Fruitland, Idaho, 83619
Casper, Wyoming, 82609
Marrero, Louisiana, 70072
Peru, Illinois, 61354
Bellingham, Washington, 98225
Carthage, Illinois, 62321
Springfield, Missouri, 65804
Henderson, Nevada, 89052
New York, New York, 10016
Traverse City, Michigan, 49684
Sedro-Woolley, Washington, 98284
Dublin, California, 94568
Pottsville, Pennsylvania, 17901
Phoenixville, Pennsylvania, 19460
Newport News, Virginia, 23601
Johnson Creek, Wisconsin, 53038
Toledo, Ohio, 43608
Lacey, Washington, 98503
Maplewood, Minnesota, 55109
Wheat Ridge, Colorado, 80033
Bremerton, Washington, 98310
Grapevine, Texas, 76053
Bloomington, Illinois, 61704
Muskegon, Michigan, 49444
Freeport, Illinois, 61032
Matthews, North Carolina, 28105
New Orleans, Louisiana, 70115
Helena, Montana, 59601
Bristol, Tennessee, 37620
Seneca, Pennsylvania, 16346
Effingham, Illinois, 62401
Atlanta, Georgia, 30342
Richmond, Virginia, 23230
Bemidji, Minnesota, 56601
Duluth, Minnesota, 55805
Greenbrae, California, 94904
Columbia, Maryland, 21044
Lakeland, Florida, 33805
Newark, New Jersey, 07112
Weston, Wisconsin, 54476
Bozeman, Montana, 59715
Wyoming, Michigan, 49519
Omaha, Nebraska, 68122
Augusta, Georgia, 30912
Honolulu, Hawaii, 96817
Decatur, Georgia, 30033
Olympia, Washington, 98507
Lihue, Hawaii, 96766
Columbia, Missouri, 65212
Neptune, New Jersey, 07753
Battle Creek, Michigan, 49017
Mount Airy, North Carolina, 27030
Honolulu, Hawaii, 96813
Shreveport, Louisiana, 71103
Hanover, Pennsylvania, 17331
Mineola, New York, 11501
Fremont, California, 94538
Mankato, Minnesota, 56001
Hartford, Connecticut, 06102
Dayton, Ohio, 45415
San Luis Obispo, California, 93401
Jupiter, Florida, 33458
Baltimore, Maryland, 21225
Madisonville, Kentucky, 42431
Mishawaka, Indiana, 46545
The Woodlands, Texas, 77380
Salt Lake City, Utah, 84106
Kettering, Ohio, 45429
Vacaville, California, 95688
Marion, North Carolina, 28752
Jacksonville, Florida, 32204
Dayton, Ohio, 45406
Lakewood, Colorado, 80228
Salina, Kansas, 67401
Maywood, Illinois, 60153
Georgetown, South Carolina, 29440
Denver, Colorado, 80210
Royal Oak, Michigan, 48073
Morgantown, West Virginia, 26506
Adrian, Michigan, 49221
Oakland, California, 94611
Rutland, Vermont, 05701
Manitowoc, Wisconsin, 54221
Danville, Virginia, 24541
Chippewa Falls, Wisconsin, 54729
Oakland, California, 94609
Manchester, Connecticut, 06040
Largo, Maryland, 20774
Sunset Hills, Missouri, 63127
Kansas City, Missouri, 64118
Honolulu, Hawaii, 96819
Flemington, New Jersey, 08822
Bolivar, Missouri, 65613
Farmington Hills, Michigan, 48334
Syracuse, New York, 13210
San Antonio, Texas, 78229
West Chester, Ohio, 45069
Sarasota, Florida, 34236
San Jose, California, 95119
Monmouth, Illinois, 61462
Cedar Rapids, Iowa, 52403
McAllen, Texas, 78503
Rome, Georgia, 30165
Manchester, New Hampshire, 03102
Montreal, Quebec, H3T 1E2
Tacoma, Washington, 98405
Princeton, Illinois, 61356
Xenia, Ohio, 45385
Fairmont, West Virginia, 26554
Rochester, New York, 14620
Corbin, Kentucky, 40701
Doylestown, Pennsylvania, 18901
Bethesda, Maryland, 20889-5600
New York, New York, 10003
Staten Island, New York, 10305
Vallejo, California, 94589
Mattoon, Illinois, 61938
Goldsboro, North Carolina, 27534
Charleston, South Carolina, 29403
Louisville, Kentucky, 40202
Long Branch, New Jersey, 07740
Sherman, Texas, 75090
Fredericksburg, Virginia, 22408
Lapeer, Michigan, 48446
Kinston, North Carolina, 28501
Letterkenny, Co Donegal
Albuquerque, New Mexico, 87102
Mukwonago, Wisconsin, 53149
Cedar City, Utah, 84720
Emeryville, California, 94608
Mountain View, California, 94040
Milford, Massachusetts, 01757
Baton Rouge, Louisiana, 70809
Edina, Minnesota, 55435
Albany, New York, 12206
Oconto Falls, Wisconsin, 54154
Rockville, Maryland, 20850
Alexandria, Minnesota, 56308
Sewell, New Jersey, 08080
Columbus, Ohio, 43210
Belpre, Ohio, 45714
Las Vegas, Nevada, 89149
Washington, District of Columbia, 20010
Greenwood Village, Colorado, 80111
The Dalles, Oregon, 97058
Covington, Louisiana, 70433
Jacksonville, North Carolina, 28546
Dublin, Georgia, 31021
Upland, Pennsylvania, 19013
Wichita Falls, Texas, 76310
Seattle, Washington, 98122-4307
New Ulm, Minnesota, 56073
Wilkes-Barre, Pennsylvania, 18711
Parkersburg, West Virginia, 26101
Decatur, Illinois, 62526
Waukesha, Wisconsin, 53188
Milwaukee, Wisconsin, 53211
Lewes, Delaware, 19958
Butte, Montana, 59701
Wichita, Kansas, 67214
Yakima, Washington, 98902
Delaware, Ohio, 43015
Council Bluffs, Iowa, 51503
Mobile, Alabama, 36608
Lakewood, Washington, 98499
Mesquite, Texas, 75150
Las Vegas, Nevada, 89106
Houston, Texas, 77030
Omaha, Nebraska, 68106
Mansfield, Ohio, 44906
Sandusky, Ohio, 44870
Troy, New York, 12180
Austell, Georgia, 30106
Westville, Indiana, 46391
New Orleans, Louisiana, 70112
San Antonio, Texas, 78217
Sparta, New Jersey, 07871
Winfield, Kansas, 67156
Richmond, California, 94801
Fort Worth, Texas, 76104
Deerfield Beach, Florida, 33442
Johnstown, Pennsylvania, 15901
Scranton, Pennsylvania, 18501
South San Francisco, California, 94080
Charleston, South Carolina, 29414
Owensboro, Kentucky, 42303
Grand Island, Nebraska, 68803
Colorado Springs, Colorado, 80907
Boone, Iowa, 50036
Merrion, Co Dublin, 4
Lincoln, Nebraska, 68510
Tulsa, Oklahoma, 74146
Dover, Delaware, 19901
Oakland, California, 94609
Salem, Oregon, 97301
Anchorage, Alaska, 99508
Hartford, Connecticut, 06105
Mount Pleasant, South Carolina, 29464
Lee's Summit, Missouri, 64086
Bronx, New York, 10461
York, Pennsylvania, 17403
La Porte, Indiana, 46350
Savannah, Georgia, 31404
Columbus, Ohio, 43215
Iowa City, Iowa, 52242
Orange, California, 92868
Des Moines, Iowa, 50316
Bel Air, Maryland, 21014
Dublin, Co Dublin, 4
Charlotte, North Carolina, 28207
Santa Rosa, California, 95403
Effingham, Illinois, 62401
Maplewood, Minnesota, 55109
Henderson, Nevada, 89052
Albany, New York, 12208
Billings, Montana, 59101
Beachwood, Ohio, 44122
Davenport, Iowa, 52803
Scranton, Pennsylvania, 18508
Anniston, Alabama, 36202
Clackamas, Oregon, 97015
Saint Louis, Missouri, 63128
Plattsburgh, New York, 12901
Petoskey, Michigan, 49770
Winchester, Virginia, 22601
Sainte Genevieve, Missouri, 63670
Englewood, Colorado, 80113
Aurora, Colorado, 80012
Hendersonville, North Carolina, 28792
Kingsport, Tennessee, 37660
Lawrenceville, Georgia, 30046
Burlington, Vermont, 05405
Mishawaka, Indiana, 46545
Louisville, Kentucky, 40202
San Francisco, California, 94115
Quincy, Massachusetts, 02169
Clive, Iowa, 50325
McLean, Virginia, 22102
Kalamazoo, Michigan, 49007
Kalamazoo, Michigan, 49048
Washington, Pennsylvania, 15301
Knoxville, Tennessee, 37916
Raleigh, North Carolina, 27607
Flint, Michigan, 48503
San Leandro, California, 94577
Tiffin, Ohio, 44883
Atlanta, Georgia, 30309
Warwick, Rhode Island, 02886
Cincinnati, Ohio, 45242
Roxboro, North Carolina, 27573
Las Vegas, Nevada, 89169
Norfolk, Nebraska, 68701
Delaware, Ohio, 43015
Norwalk, Ohio, 44857
Scottsbluff, Nebraska, 69361
Saint Louis, Missouri, 63109
Austin, Texas, 78745
New Haven, Connecticut, 06520
Baltimore, Maryland, 21215
Littleton, Colorado, 80122
Midland, Michigan, 48670
Parker, Colorado, 80138
Baton Rouge, Louisiana, 70806
Salisbury, Maryland, 21801
Boise, Idaho, 83712
Dallas, Texas, 75231
Crestview Hills, Kentucky, 41017
Seaford, Delaware, 19973
Park Ridge, Illinois, 60068
Olympia, Washington, 98506-5166
Michigan City, Indiana, 46360
Overland Park, Kansas, 66213
Commerce, Michigan, 48382
Greenville, South Carolina, 29607
Minneapolis, Minnesota, 55454
Dublin, Co Dublin, 9
Clifton Park, New York, 12065
San Juan, 00936
Kissimmee, Florida, 34744
Flint, Michigan, 48532
Colorado Springs, Colorado, 80909

Tracking Information

NCT #
NCT01275677
Collaborators
NRG Oncology
Investigators
  • Principal Investigator: Louis Fehrenbacher NRG Oncology
  • Louis Fehrenbacher NRG Oncology