BRCA Mutations in Latinas

Summary

Participation Requirements

Description

BACKGROUND: Mutations in the BRCA1 and BRCA2 genes predispose to breast and ovarian cancer, and are increasingly recognized in prostate and pancreatic cancers. Basal/ Triple negative breast cancer is associated with BRCA mutations in some ethnicities.However the link between BRCA gene mutations and ...

BACKGROUND: Mutations in the BRCA1 and BRCA2 genes predispose to breast and ovarian cancer, and are increasingly recognized in prostate and pancreatic cancers. Basal/ Triple negative breast cancer is associated with BRCA mutations in some ethnicities.However the link between BRCA gene mutations and Basil/ triple negative disease in Hispanic/ Latino women is not known. Common recurrent mutations in BRCA1 and BRCA2 exist in Hispanic/ Latino communities. New therapies such as PARP inhibitors may be particularly effective in BRCA mutation carriers. Therefore a unique opportunity exists to identify women in this underserved minority that may be eligible for and benefit from new targeted therapies. OBJECTIVES: - The primary objective is to collect saliva samples and histology data from up to 2000 Hispanic/ Latino subjects with breast cancer as a source of DNA, and to analyze the BRCA1 and BRCA2 genes.. ELIGIBILITY: - All Hispanics females, over the age of 18, with breast cancer will be eligible. DESIGN: - Natural history study of 2000 Hispanic/Latino women with breast cancer, 1000 with triple negative disease, 1000 without. Obtain clinical pathology reports and relevant history data on all subjects. Analyze recurrent BRCA1 and BRCA2 mutations

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