Ofatumumab-based Induction Chemoimmunotherapy in Previously Untreated Patients With CLL/SLL
Last updated on July 2021Recruitment
- Recruitment Status
- Active, not recruiting
- Estimated Enrollment
- 46
Summary
- Conditions
- CLL (Chronic Lymphocytic Leukemia)
- Small Lymphocytic Lymphoma
- Type
- Interventional
- Phase
- Phase 2
- Design
- Allocation: Non-RandomizedIntervention Model: Parallel AssignmentMasking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 99 years
- Gender
- Both males and females
Description
OUTLINE: Patients with adverse interphase cytogenetics (11q22 or 17p13 deletion) receive FCO induction therapy: Ofatumumab is given IV on day 1 (300 mg) and day 8 (1000 mg) of course 1 and on day 1 (1000 mg) of all subsequent courses. Fludarabine phosphate (25mg/m2/d) and cyclophosphamide (250mg/m2/...
OUTLINE: Patients with adverse interphase cytogenetics (11q22 or 17p13 deletion) receive FCO induction therapy: Ofatumumab is given IV on day 1 (300 mg) and day 8 (1000 mg) of course 1 and on day 1 (1000 mg) of all subsequent courses. Fludarabine phosphate (25mg/m2/d) and cyclophosphamide (250mg/m2/d) are given IV on days 2 through 4 of course 1 and on days 1 through 3 of all subsequent courses. Patients age 70 or older will be given reduced <TAB>doses of fludarabine (20mg/m2/d) and cyclophosphamide (150mg/m2/d). Treatment repeats every 28 days for up to 6 courses in the absence of disease progression. Patients without adverse interphase cytogenetics receive FO induction therapy: Ofatumumab is given IV on day 1 (300mg) and day 8 (1000mg) of course 1 and on day 1 (1000mg) of all subsequent courses. Fludarabine phosphate (25mg/m2/d) is given IV on days 2 through 6 of course 1 and on days 1 through 5 of all subsequent courses. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression. All patients are evaluated for minimal residual disease (MRD) by four-color flow cytometric analysis of the peripheral blood after completion of FO or FCO induction therapy, and are subsequently stratified into two groups: Patients who are MRD-positive and without evidence of disease progression proceed to consolidation <TAB>therapy beginning approximately 5 months after completion of induction therapy, consisting of ofatumumab (1000mg) given IV on day 1 of all courses. Treatment repeats every 2 months for up to 4 courses in the absence of disease progression. Patients are followed clinically 2 and 6 months after the last dose of ofatumumab is given, and then every 6 months thereafter. Patients who are MRD-negative and without evidence of disease progression are followed clinically every 4 months for 1 year and every 6 months thereafter.
Tracking Information
- NCT #
- NCT01145209
- Collaborators
- University of Virginia
- GlaxoSmithKline
- Investigators
- Principal Investigator: Inhye Ahn, M.D. National Heart, Lung, and Blood Institute (NHLBI)