Recruitment

Recruitment Status
Recruiting
Estimated Enrollment
Same as current

Summary

Conditions
  • Cytomegalovirus Infections
  • Pregnant Women
Type
Observational
Design
Observational Model: Case-ControlTime Perspective: Cross-Sectional

Participation Requirements

Age
Between 18 years and 50 years
Gender
Only males

Description

Fetal infection with CMV is the most common cause of intrauterine infection. Only 40% of pregnant women with primary CMV transmit the virus to their fetus. Many of these women are referred to amniocentesis and many elect to terminate pregnancy without knowledge about fetal infection or damage. Curre...

Fetal infection with CMV is the most common cause of intrauterine infection. Only 40% of pregnant women with primary CMV transmit the virus to their fetus. Many of these women are referred to amniocentesis and many elect to terminate pregnancy without knowledge about fetal infection or damage. Currently it is assumed that transmission is dictated by variety of factors including maternal and fetal immune system. Efforts to find correlation between maternal immune system and fetal infection which can be used as a diagnostic marker were unsuccessful. Our hypothesis is that there is a correlation between cellular immune response of the mother to CMV infection and viral transmission to the fetus. Pregnant women with primary CMV infection (40% of whom are expected to be transmitters)and with pre-conception immunity will participate in this study. Blood from these women will be incubated with CMV peptides and T cell activation will be measured by the secretion of various cytokines.

Tracking Information

NCT #
NCT01081379
Collaborators
Not Provided
Investigators
Principal Investigator: Yechiel Schlesinger, M.D. Shaare Zedek Medical Center