Recruitment

Recruitment Status
Active, not recruiting
Estimated Enrollment
415

Inclusion Criteria

Platelet count greater than or equal to 100,000/mcL
Any hormonal therapy directed at the malignant tumor must be discontinued at least one week prior to beginning protocol chemotherapy; continuation of hormone replacement therapy is permitted
Gynecologic Oncology Group (GOG) performance status 0, 1, or 2
...
Platelet count greater than or equal to 100,000/mcL
Any hormonal therapy directed at the malignant tumor must be discontinued at least one week prior to beginning protocol chemotherapy; continuation of hormone replacement therapy is permitted
Gynecologic Oncology Group (GOG) performance status 0, 1, or 2
Patients may have received prior adjuvant external beam radiation therapy and/or vaginal brachytherapy; patients should be at least 4 weeks from the completion of external beam radiotherapy prior to beginning protocol chemotherapy; patients do not need to be delayed if receiving vaginal brachytherapy only
Creatinine less than or equal to 1.5 times upper limit of normal (ULN), CTCAE v3.0 grade 1
Serum glutamic oxaloacetic transaminase (SGOT) less than or equal to 2.5 times ULN (CTCAE v3.0 grade 1)
Alkaline phosphatase less than or equal to 2.5 times ULN (CTCAE v3.0 grade 1)
Patients must have recovered from the effects of recent surgery, radiotherapy, or other therapy
Patients may have measurable disease or non-measurable disease; measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest dimension to be recorded); each lesion must be >= 20 mm when measured by conventional techniques, including palpation, plain x-ray, computed tomography (CT), and magnetic resonance imaging (MRI), or >= 10 mm when measured by spiral CT; measurable disease patients must have at least one "target lesion" to be used to assess progression on this protocol as defined by Response Evaluation Criteria In Solid Tumors (RECIST); tumors within a previously irradiated field will be designated as "non-target" lesions unless progression is documented or a biopsy is obtained to confirm persistence at least 90 days following completion of radiation therapy
Patients must have newly diagnosed stage I-IV, persistent or recurrent (including unstaged) uterine carcinosarcoma (malignant mixed mullerian tumor-MMMT or with ovarian, fallopian tube or peritoneal carcinosarcoma and an enrollment date prior to 10/21/2013; pathology confirmed by site/institutional pathologist prior to enrollment) and be chemotherapy naïve as directed against their carcinosarcoma; unstaged patients (patients who have not had hysterectomy or ovarian surgery) are eligible and should be included as "unstaged" if the only histologic (pathology) documentation of the disease is a biopsy or curettage of the uterus; if these patients have documented metastatic disease, it should be assigned the appropriate stage (III/IV)
Patients of childbearing potential must have a negative serum pregnancy test prior to study entry and be practicing an effective form of contraception
Neuropathy (sensory and motor) less than or equal to CTCAE v3.0 grade 1
Patients must be free of active infection requiring antibiotics
Serum albumin should be equal to or greater than 3 g/dL
Patients must have signed an approved informed consent and authorization permitting release of personal health information
Absolute neutrophil count (ANC) greater than or equal to 1,500/mcL equivalent to Common Terminology Criteria for Adverse Events (CTCAE) version (v)3.0 grade 1
Bilirubin less than or equal to 1.5 times ULN (CTCAE v3.0 grade 1)

Exclusion Criteria

Patients who have received prior cytotoxic chemotherapy for management of uterine or ovarian carcinosarcoma
Patients with a known hypersensitivity to mesna or other thiol compounds
Patients with a history of other invasive malignancies or with a concomitant invasive malignancy, with the exception of non-melanoma skin cancer, if there is any evidence of other malignancy being present within the last five years; patients are also ineligible if their previous cancer treatment contraindicates this protocol therapy
...
Patients who have received prior cytotoxic chemotherapy for management of uterine or ovarian carcinosarcoma
Patients with a known hypersensitivity to mesna or other thiol compounds
Patients with a history of other invasive malignancies or with a concomitant invasive malignancy, with the exception of non-melanoma skin cancer, if there is any evidence of other malignancy being present within the last five years; patients are also ineligible if their previous cancer treatment contraindicates this protocol therapy
Patients for whom radiotherapy is planned after or during chemotherapy prior to progression of cancer
For enrollment prior to 10/21/2013, patients who are not biopsy proven to have carcinosarcoma of the uterus, fallopian tube, peritoneum or ovary; for enrollment after 10/21/2013, patients who are not biopsy proven to have carcinosarcoma of the uterus
Patients with known hypersensitivity to Escherichia (E.) coli-derived drug preparations (pegfilgrastim and filgrastim [G-CSF])

Summary

Conditions
  • Stage IA Fallopian Tube Cancer AJCC v6 and v7
  • Recurrent Primary Peritoneal Carcinoma
  • Mixed Mesodermal (Mullerian) Tumor
  • Stage IIA Fallopian Tube Cancer AJCC v6 and v7
  • Stage IIIB Fallopian Tube Cancer AJCC v7
  • Stage IV Primary Peritoneal Cancer AJCC v7
  • Stage IC Fallopian Tube Cancer AJCC v6 and v7
  • Stage IIA Ovarian Cancer AJCC V6 and v7
  • Stage IIB Fallopian Tube Cancer AJCC v6 and v7
  • Ovarian Carcinosarcoma
  • Recurrent Fallopian Tube Carcinoma
  • Recurrent Ovarian Carcinoma
  • Stage IVA Uterine Sarcoma AJCC v7
  • Stage I Ovarian Cancer AJCC v6 and v7
  • Stage IIB Ovarian Cancer AJCC v6 and v7
  • Stage IIIB Primary Peritoneal Cancer AJCC v7
  • Stage IIIC Primary Peritoneal Cancer AJCC v7
  • Stage IIIC Fallopian Tube Cancer AJCC v7
  • Stage IIIA Primary Peritoneal Cancer AJCC v7
  • Stage IIIB Ovarian Cancer AJCC v6 and v7
  • Stage IA Ovarian Cancer AJCC v6 and v7
  • Stage II Ovarian Cancer AJCC v6 and v7
  • Stage IA Uterine Sarcoma AJCC v7
  • Uterine Carcinosarcoma
  • Stage IIC Ovarian Cancer AJCC v6 and v7
  • Stage IC Ovarian Cancer AJCC v6 and v7
  • Stage IV Ovarian Cancer AJCC v6 and v7
  • Stage IIIC Ovarian Cancer AJCC v6 and v7
  • Stage IIIC Uterine Sarcoma AJCC v7
  • Stage IIA Uterine Sarcoma AJCC v7
  • Stage IB Fallopian Tube Cancer AJCC v6 and v7
  • Stage IIIA Fallopian Tube Cancer AJCC v7
  • Stage IIIB Uterine Sarcoma AJCC v7
  • Stage IIIA Ovarian Cancer AJCC v6 and v7
  • Stage IIB Uterine Sarcoma AJCC v7
  • Stage IVB Uterine Sarcoma AJCC v7
  • Stage IB Uterine Sarcoma AJCC v7
  • Stage IC Uterine Sarcoma AJCC v7
  • Stage IB Ovarian Cancer AJCC v6 and v7
  • Stage IIC Fallopian Tube Cancer AJCC v6 and v7
  • Stage IV Fallopian Tube Cancer AJCC v6 and v7
  • Stage IIIA Uterine Sarcoma AJCC v7
Type
Interventional
Phase
Phase 3
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 18 years and 125 years
Gender
Only females

Description

PRIMARY OBJECTIVES: I. To determine if treatment with combination paclitaxel and carboplatin (TC) chemotherapy does not result in an inferior death rate when compared to ifosfamide, mesna, and paclitaxel chemotherapy. SECONDARY OBJECTIVES: I. To determine if treatment with combination paclitaxel and...

PRIMARY OBJECTIVES: I. To determine if treatment with combination paclitaxel and carboplatin (TC) chemotherapy does not result in an inferior death rate when compared to ifosfamide, mesna, and paclitaxel chemotherapy. SECONDARY OBJECTIVES: I. To determine if treatment with combination paclitaxel and carboplatin (TC) chemotherapy does not result in an inferior progression-free survival when compared to ifosfamide, mesna, and paclitaxel chemotherapy. II. To determine if acute toxicity, specifically physician-assessed neurotoxicity and infection, associated with combination paclitaxel and carboplatin chemotherapy is reduced compared to that of ifosfamide, mesna, and paclitaxel chemotherapy. III. To determine if treatment with combination paclitaxel and carboplatin chemotherapy is associated with superior patient-reported quality of life and neurotoxicity scores compared to that of ifosfamide, mesna, and paclitaxel chemotherapy. TERTIARY OBJECTIVES: I. To bank formalin-fixed, paraffin-embedded (FFPE) tumor tissue and deoxyribonucleic acid (DNA) extracted from whole blood for future research. OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM I: Patients receive paclitaxel intravenously (IV) over 3 hours followed by carboplatin IV over 30-60 minutes on day 1. ARM II: Patients receive ifosfamide IV over 1 hour on days 1-3 followed by paclitaxel as in Arm I. In both arms, treatment repeats every 21 days for 6-10 courses in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

Inclusion Criteria

Platelet count greater than or equal to 100,000/mcL
Any hormonal therapy directed at the malignant tumor must be discontinued at least one week prior to beginning protocol chemotherapy; continuation of hormone replacement therapy is permitted
Gynecologic Oncology Group (GOG) performance status 0, 1, or 2
...
Platelet count greater than or equal to 100,000/mcL
Any hormonal therapy directed at the malignant tumor must be discontinued at least one week prior to beginning protocol chemotherapy; continuation of hormone replacement therapy is permitted
Gynecologic Oncology Group (GOG) performance status 0, 1, or 2
Patients may have received prior adjuvant external beam radiation therapy and/or vaginal brachytherapy; patients should be at least 4 weeks from the completion of external beam radiotherapy prior to beginning protocol chemotherapy; patients do not need to be delayed if receiving vaginal brachytherapy only
Creatinine less than or equal to 1.5 times upper limit of normal (ULN), CTCAE v3.0 grade 1
Serum glutamic oxaloacetic transaminase (SGOT) less than or equal to 2.5 times ULN (CTCAE v3.0 grade 1)
Alkaline phosphatase less than or equal to 2.5 times ULN (CTCAE v3.0 grade 1)
Patients must have recovered from the effects of recent surgery, radiotherapy, or other therapy
Patients may have measurable disease or non-measurable disease; measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest dimension to be recorded); each lesion must be >= 20 mm when measured by conventional techniques, including palpation, plain x-ray, computed tomography (CT), and magnetic resonance imaging (MRI), or >= 10 mm when measured by spiral CT; measurable disease patients must have at least one "target lesion" to be used to assess progression on this protocol as defined by Response Evaluation Criteria In Solid Tumors (RECIST); tumors within a previously irradiated field will be designated as "non-target" lesions unless progression is documented or a biopsy is obtained to confirm persistence at least 90 days following completion of radiation therapy
Patients must have newly diagnosed stage I-IV, persistent or recurrent (including unstaged) uterine carcinosarcoma (malignant mixed mullerian tumor-MMMT or with ovarian, fallopian tube or peritoneal carcinosarcoma and an enrollment date prior to 10/21/2013; pathology confirmed by site/institutional pathologist prior to enrollment) and be chemotherapy naïve as directed against their carcinosarcoma; unstaged patients (patients who have not had hysterectomy or ovarian surgery) are eligible and should be included as "unstaged" if the only histologic (pathology) documentation of the disease is a biopsy or curettage of the uterus; if these patients have documented metastatic disease, it should be assigned the appropriate stage (III/IV)
Patients of childbearing potential must have a negative serum pregnancy test prior to study entry and be practicing an effective form of contraception
Neuropathy (sensory and motor) less than or equal to CTCAE v3.0 grade 1
Patients must be free of active infection requiring antibiotics
Serum albumin should be equal to or greater than 3 g/dL
Patients must have signed an approved informed consent and authorization permitting release of personal health information
Absolute neutrophil count (ANC) greater than or equal to 1,500/mcL equivalent to Common Terminology Criteria for Adverse Events (CTCAE) version (v)3.0 grade 1
Bilirubin less than or equal to 1.5 times ULN (CTCAE v3.0 grade 1)

Exclusion Criteria

Patients who have received prior cytotoxic chemotherapy for management of uterine or ovarian carcinosarcoma
Patients with a known hypersensitivity to mesna or other thiol compounds
Patients with a history of other invasive malignancies or with a concomitant invasive malignancy, with the exception of non-melanoma skin cancer, if there is any evidence of other malignancy being present within the last five years; patients are also ineligible if their previous cancer treatment contraindicates this protocol therapy
...
Patients who have received prior cytotoxic chemotherapy for management of uterine or ovarian carcinosarcoma
Patients with a known hypersensitivity to mesna or other thiol compounds
Patients with a history of other invasive malignancies or with a concomitant invasive malignancy, with the exception of non-melanoma skin cancer, if there is any evidence of other malignancy being present within the last five years; patients are also ineligible if their previous cancer treatment contraindicates this protocol therapy
Patients for whom radiotherapy is planned after or during chemotherapy prior to progression of cancer
For enrollment prior to 10/21/2013, patients who are not biopsy proven to have carcinosarcoma of the uterus, fallopian tube, peritoneum or ovary; for enrollment after 10/21/2013, patients who are not biopsy proven to have carcinosarcoma of the uterus
Patients with known hypersensitivity to Escherichia (E.) coli-derived drug preparations (pegfilgrastim and filgrastim [G-CSF])

Locations

Bethlehem, Pennsylvania, 18015
Saint Louis, Missouri, 63110
Liberal, Kansas, 67905
Buffalo, New York, 14263
Springfield, Missouri, 65804
...
Bethlehem, Pennsylvania, 18015
Saint Louis, Missouri, 63110
Liberal, Kansas, 67905
Buffalo, New York, 14263
Springfield, Missouri, 65804
Havre, Montana, 59501
Toledo, Ohio, 43608
Indianapolis, Indiana, 46260
Cleveland, Ohio, 44106
New Orleans, Louisiana, 70121
Decatur, Illinois, 62526
Princeton, Illinois, 61356
Macomb, Illinois, 61455
Independence, Missouri, 64057
Burlington, Vermont, 05401
Fredericksburg, Virginia, 22401
Lone Tree, Colorado, 80124
Zanesville, Ohio, 43701
Baltimore, Maryland, 21215
Wellington, Kansas, 67152
Seoul, 05505
Normal, Illinois, 61761
Auburn, Washington, 98001
Springfield, Massachusetts, 01199
Salina, Kansas, 67401
Peoria, Illinois, 61614
Charlotte, North Carolina, 28203
Jackson, Michigan, 49201
Toledo, Ohio, 43623
Missoula, Montana, 59802
Colorado Springs, Colorado, 80907
Spokane, Washington, 99204
Washington, District of Columbia, 20010
Seattle, Washington, 98104
Monmouth, Illinois, 61462
Findlay, Ohio, 45840
Peru, Illinois, 61354
Casper, Wyoming, 82609
Reno, Nevada, 89502
Cape Girardeau, Missouri, 63703
Newton, Kansas, 67114
Kalispell, Montana, 59901
Mukwonago, Wisconsin, 53149
Sheboygan, Wisconsin, 53081
Pratt, Kansas, 67124
Dayton, Ohio, 45409
Eureka, Illinois, 61530
Saint Paul, Minnesota, 55102
Elkhart, Indiana, 46515
Missoula, Montana, 59802
Lima, Ohio, 45804
Winston-Salem, North Carolina, 27157
Bellevue, Washington, 98004
Urbana, Illinois, 61801
Bryn Mawr, Pennsylvania, 19010
Fargo, North Dakota, 58122
Miami, Florida, 33133
Baltimore, Maryland, 21201
Manhattan, Kansas, 66502
Normal, Illinois, 61761
Dallas, Texas, 75235
Kalamazoo, Michigan, 49007
Bemidji, Minnesota, 56601
Greenville, Ohio, 45331
Omaha, Nebraska, 68114
Des Moines, Iowa, 50309
Pekin, Illinois, 61554
Seattle, Washington, 98122-4307
Wenatchee, Washington, 98801
Jung-Ku, Daegu, 700-712
Monroe, Michigan, 48162
New Brunswick, New Jersey, 08903
Paoli, Pennsylvania, 19301
Springfield, Missouri, 65807
Scottsdale, Arizona, 85259
Dayton, Ohio, 45415
Springfield, Illinois, 62781
Grand Rapids, Michigan, 49503
Bloomington, Illinois, 61704
Delaware, Ohio, 43015
Hinsdale, Illinois, 60521
Walnut Creek, California, 94598
New Haven, Connecticut, 06520
Port Huron, Michigan, 48060
Dearborn, Michigan, 48124
Lee's Summit, Missouri, 64086
Flint, Michigan, 48503
Warrenville, Illinois, 60555
Wichita, Kansas, 67208
Knoxville, Tennessee, 37920
Princeton, Illinois, 61356
Sacramento, California, 95816
Wichita, Kansas, 67214
New Ulm, Minnesota, 56073
Franklin, Ohio, 45005-1066
Grafton, Wisconsin, 53024
Federal Way, Washington, 98003
Walla Walla, Washington, 99362
Woodbury, Minnesota, 55125
Bremerton, Washington, 98310
Summit, Wisconsin, 53066
Burbank, California, 91505
Ottawa, Illinois, 61350
Pueblo, Colorado, 81004
Tiffin, Ohio, 44883
Saint Louis Park, Minnesota, 55416
Spokane, Washington, 99202
Seoul, 139-706
Mountain View, California, 94040
Chicago, Illinois, 60611
Clive, Iowa, 50325
Oregon, Ohio, 43616
Fairfield, Ohio, 45014
Columbus, Ohio, 43214
Pekin, Illinois, 61554
Canton, Illinois, 61520
Big Rapids, Michigan, 49307
Billings, Montana, 59101
Fresh Meadows, New York, 11365
Camden, New Jersey, 08103
Valhalla, New York, 10595
Durham, North Carolina, 27710
Lexington, Kentucky, 40536
Canton, Illinois, 61520
Columbus, Ohio, 43214
Milwaukee, Wisconsin, 53226
Parsons, Kansas, 67357
Kalamazoo, Michigan, 49048
Westville, Indiana, 46391
Loveland, Colorado, 80539
Mount Vernon, Illinois, 62864
Shreveport, Louisiana, 71103
Los Angeles, California, 90048
Wichita, Kansas, 67214
Ann Arbor, Michigan, 48109
Mount Holly, New Jersey, 08060
Kansas City, Missouri, 64132
La Porte, Indiana, 46350
South Bend, Indiana, 46601
Seattle, Washington, 98109
Rapid City, South Dakota, 57701
Waukesha, Wisconsin, 53188
Wheat Ridge, Colorado, 80033
Wichita, Kansas, 67214
New York, New York, 10065
Seoul, 135-720
Wynnewood, Pennsylvania, 19096
Sioux Falls, South Dakota, 57104
Cincinnati, Ohio, 45230
Voorhees, New Jersey, 08043
Two Rivers, Wisconsin, 54241
Joplin, Missouri, 64804
Milwaukee, Wisconsin, 53233
Stony Brook, New York, 11794
Philadelphia, Pennsylvania, 19111
Poulsbo, Washington, 98370
Savannah, Georgia, 31404
Albuquerque, New Mexico, 87106
Greenville, South Carolina, 29605
Waconia, Minnesota, 55387
Adrian, Michigan, 49221
Billings, Montana, 59102
Grand Junction, Colorado, 81501
Columbus, Ohio, 43222
Saint Louis Park, Minnesota, 55416
Columbia, Missouri, 65212
Saint Louis, Missouri, 63141
Oshkosh, Wisconsin, 54904
Easley, South Carolina, 29640
Elkton, Maryland, 21921
Delaware, Ohio, 43015
New Richmond, Wisconsin, 54017
Wilkes-Barre, Pennsylvania, 18711
Tacoma, Washington, 98405
La Jolla, California, 92093
Allentown, Pennsylvania, 18103
Iowa City, Iowa, 52242
Mount Vernon, Washington, 98274
Los Angeles, California, 90027
Galesburg, Illinois, 61401
Sioux Falls, South Dakota, 57117-5134
Des Moines, Iowa, 50314
Decatur, Illinois, 62526
Crestview Hills, Kentucky, 41017
Tulsa, Oklahoma, 74146
Great Falls, Montana, 59405
Flint, Michigan, 48503
Charleston, South Carolina, 29425
Columbus, Ohio, 43228
Monroe, Michigan, 48162
Tucson, Arizona, 85719
Sylmar, California, 91342
Lakewood, Colorado, 80228
Hershey, Pennsylvania, 17033-0850
Boulder, Colorado, 80304
Fort Myers, Florida, 33905
Brightwaters, New York, 11718
Pittsburgh, Pennsylvania, 15224
Wauseon, Ohio, 43567
Maywood, Illinois, 60153
Greenville, South Carolina, 29601
Flint, Michigan, 48532
South Bend, Indiana, 46628
Ann Arbor, Michigan, 48106
Seattle, Washington, 98195
New Britain, Connecticut, 06050
Denver, Colorado, 80222
Denver, Colorado, 80218
Billings, Montana, 59102
Syracuse, New York, 13210
Columbus, Ohio, 43215
Helena, Montana, 59601
Lake Success, New York, 11042
Burlington, North Carolina, 27215
Chapel Hill, North Carolina, 27599
Niles, Michigan, 49120
Boise, Idaho, 83706
Minneapolis, Minnesota, 55415
Detroit, Michigan, 48236
Maumee, Ohio, 43537
Concord, California, 94520
Baltimore, Maryland, 21204
Michigan City, Indiana, 46360
Milwaukee, Wisconsin, 53215
Norwich, Connecticut, 06360
Mobile, Alabama, 36688
Sheridan, Wyoming, 82801
Natrona Heights, Pennsylvania, 15065
Tucson, Arizona, 85704
Ottawa, Illinois, 61350
Greenwood, South Carolina, 29646
Overland Park, Kansas, 66213
Colorado Springs, Colorado, 80907
Stillwater, Minnesota, 55082
Newark, Delaware, 19718
Sioux City, Iowa, 51104
Chicago, Illinois, 60637
Houston, Texas, 77030
Toledo, Ohio, 43614
El Dorado, Kansas, 67042
Greenville, South Carolina, 29615
Mentor, Ohio, 44060
Carthage, Illinois, 62321
Greenwood Village, Colorado, 80111
Denver, Colorado, 80218
Aurora, Illinois, 60504
Omaha, Nebraska, 68198
Lone Tree, Colorado, 80124
Phoenix, Arizona, 85054
West Des Moines, Iowa, 50266
Macon, Georgia, 31201
Eureka, Illinois, 61530
Olympia, Washington, 98506-5166
Pontiac, Michigan, 48341
Birmingham, Alabama, 35233
Reno, Nevada, 89502
Oklahoma City, Oklahoma, 73104
Lebanon, New Hampshire, 03756
Monroeville, Pennsylvania, 15146
Akron, Ohio, 44304
Grand Blanc, Michigan, 48439
Anderson, South Carolina, 29621
Greer, South Carolina, 29651
Maumee, Ohio, 43537
Saginaw, Michigan, 48601
Springfield, Missouri, 65804
Shakopee, Minnesota, 55379
Hazleton, Pennsylvania, 18201
Everett, Washington, 98201
Maplewood, Minnesota, 55109
Los Angeles, California, 90095
Kansas City, Missouri, 64118
Chillicothe, Ohio, 45601
Kettering, Ohio, 45429
Kansas City, Kansas, 66160
Kinston, North Carolina, 28501
Westerville, Ohio, 43081
Fergus Falls, Minnesota, 56537
South Bend, Indiana, 46617
Royal Oak, Michigan, 48073
Roseville, California, 95661
Akron, Ohio, 44307
Burnsville, Minnesota, 55337
Wilmington, Ohio, 45177
Orange, California, 92868
Kingman, Kansas, 67068
Seattle, Washington, 98112
Seneca, South Carolina, 29672
Denver, Colorado, 80218
Robbinsdale, Minnesota, 55422
Wichita, Kansas, 67214
Brooklyn, New York, 11203
Bellingham, Washington, 98226
Cincinnati, Ohio, 45236
Dayton, Ohio, 45459
Baltimore, Maryland, 21237
Lima, Ohio, 45801
Fargo, North Dakota, 58122
Billings, Montana, 59101
Hartford, Connecticut, 06102
Plymouth, Indiana, 46563
Battle Creek, Michigan, 49017
Staten Island, New York, 10305
Sacramento, California, 95817
Madison, Wisconsin, 53792
Mayfield Heights, Ohio, 44124
Fort Scott, Kansas, 66701
Salt Lake City, Utah, 84112
Mishawaka, Indiana, 46545
Cincinnati, Ohio, 45211
Indianapolis, Indiana, 46202
Troy, Michigan, 48085
Kansas City, Missouri, 64116
Independence, Kansas, 67301
Fridley, Minnesota, 55432
New York, New York, 10029
Peru, Illinois, 61354
Bowling Green, Ohio, 43402
Toledo, Ohio, 43623
Belpre, Ohio, 45714
Lansing, Michigan, 48912
Concord, North Carolina, 28025
Joplin, Missouri, 64804
Saint Paul, Minnesota, 55101
Longmont, Colorado, 80501
Stamford, Connecticut, 06904
Thornton, Colorado, 80229
Des Moines, Iowa, 50309
Anderson, South Carolina, 29621
Xenia, Ohio, 45385
Newark, New Jersey, 07101
Hendersonville, North Carolina, 28792
Wynnewood, Pennsylvania, 19096
Dodge City, Kansas, 67801
San Francisco, California, 94115
Newport Beach, California, 92663
Willmar, Minnesota, 56201
Denver, Colorado, 80220
Las Vegas, Nevada, 89169
Fort Worth, Texas, 76104
Rolla, Missouri, 65401
Philadelphia, Pennsylvania, 19140
Hutchinson, Minnesota, 55350
Jonesboro, Arkansas, 72401
Havana, Illinois, 62644
Philadelphia, Pennsylvania, 19107
Wyoming, Michigan, 49519
Southfield, Michigan, 48075
Winfield, Kansas, 67156
Goyang-si, Gyeonggi-do, 410-769
Hackensack, New Jersey, 07601
Longmont, Colorado, 80501
Warren, Michigan, 48093
Dayton, Ohio, 45405
Cincinnati, Ohio, 45219
Greenville, South Carolina, 29601
Saint Joseph, Michigan, 49085
Elkhart, Indiana, 46514
Kansas City, Missouri, 64114
Palo Alto, California, 94304
Charlotte, North Carolina, 28204
Cleveland, Ohio, 44109
Kansas City, Kansas, 66112
Oak Lawn, Illinois, 60453-2699
Los Angeles, California, 90033
Baton Rouge, Louisiana, 70817
Normal, Illinois, 61761
Seattle, Washington, 98109
Cleveland, Ohio, 44111
Columbus, Ohio, 43210
Chicago, Illinois, 60612
Sequim, Washington, 98384
Peoria, Illinois, 61615
Liberty, Missouri, 64068
Spartanburg, South Carolina, 29303
Troy, Ohio, 45373
Bloomington, Illinois, 61701
Farmington Hills, Michigan, 48334
Coon Rapids, Minnesota, 55433
South Bend, Indiana, 46601
West Des Moines, Iowa, 50266-7700
Seoul, 110-744
La Crosse, Wisconsin, 54601
Maplewood, Minnesota, 55109
Mishawaka, Indiana, 46545
Sioux Falls, South Dakota, 57105
Lakeland, Florida, 33805
Greeley, Colorado, 80631
New York, New York, 10065
Bolivar, Missouri, 65613
Edina, Minnesota, 55435
Monmouth, Illinois, 61462
McPherson, Kansas, 67460
Jackson, Mississippi, 39216
Peru, Illinois, 61354
Carthage, Illinois, 62321
Danville, Pennsylvania, 17822
Atlanta, Georgia, 30309
Great Falls, Montana, 59405
Phoenix, Arizona, 85013
Greenville, South Carolina, 29605
Cincinnati, Ohio, 45242
Greenville, South Carolina, 29605
Kalispell, Montana, 59901
Los Angeles, California, 90033
Muskegon, Michigan, 49444
Des Moines, Iowa, 50316
Canton, Ohio, 44710
Golden, Colorado, 80401
Nashville, Tennessee, 37232
Denver, Colorado, 80220
Tacoma, Washington, 98405
Minneapolis, Minnesota, 55407
Cleveland, Ohio, 44195
Kalispell, Montana, 59901
Columbus, Georgia, 31904
Rolla, Missouri, 65401
Grand Rapids, Michigan, 49503
Adrian, Michigan, 49221
Denver, Colorado, 80210
Seattle, Washington, 98133
Newark, Ohio, 43055
Louisville, Kentucky, 40202
Fargo, North Dakota, 58122
Kewanee, Illinois, 61443
Hartford, Connecticut, 06105
Spartanburg, South Carolina, 29307
Centralia, Washington, 98531
Aurora, Colorado, 80045
Peoria, Illinois, 61637
Bremerton, Washington, 98310
Lakewood, Washington, 98499
Detroit, Michigan, 48202
Kalamazoo, Michigan, 49007
Livonia, Michigan, 48154
Dayton, Ohio, 45406
Lakewood, Colorado, 80228
Galesburg, Illinois, 61401
Orlando, Florida, 32803
Valhalla, New York, 10595
Beech Grove, Indiana, 46107
Orange, California, 92868
Augusta, Georgia, 30912
Bethlehem, Pennsylvania, 18017
Mishawaka, Indiana, 46545
Aurora, Colorado, 80012
West Allis, Wisconsin, 53227
Richmond, Indiana, 47374
New Hyde Park, New York, 11040
Toledo, Ohio, 43606
Portsmouth, Ohio, 45662
Albany, New York, 12208
Peoria, Illinois, 61615
Jacksonville, Florida, 32224-9980
Havana, Illinois, 62644
Des Moines, Iowa, 50314
Sioux City, Iowa, 51101
Parker, Colorado, 80138
Indianapolis, Indiana, 46237
Abington, Pennsylvania, 19001
Richmond, Virginia, 23298
Reed City, Michigan, 49677
Englewood, Colorado, 80113
Denver, Colorado, 80218
Lancaster, Ohio, 43130
Branson, Missouri, 65616
Lawrence, Kansas, 66044
Mount Vernon, Ohio, 43050
Kansas City, Missouri, 64108
State College, Pennsylvania, 16801
Toledo, Ohio, 43617
Peoria, Illinois, 61636
Cincinnati, Ohio, 45202
Providence, Rhode Island, 02905
Greer, South Carolina, 29650
Galveston, Texas, 77555-0565
Dallas, Texas, 75390
Bozeman, Montana, 59715
Butte, Montana, 59701
Springfield, Ohio, 45505
Spring Valley, Illinois, 61362
Orlando, Florida, 32806
Durango, Colorado, 81301
Littleton, Colorado, 80122
Bethesda, Maryland, 20889-5600
Manhasset, New York, 11030
Kansas City, Missouri, 64111
Rochester, Minnesota, 55905
Tucson, Arizona, 85719
Saint Louis, Missouri, 63110
Columbus, Ohio, 43219
Parker, Colorado, 80138
Saint Louis, Missouri, 63109
Clive, Iowa, 50325
Boulder, Colorado, 80301
Chanute, Kansas, 66720
Oconomowoc, Wisconsin, 53066
Lewes, Delaware, 19958
Ames, Iowa, 50010
Rutherfordton, North Carolina, 28139
Marietta, Ohio, 45750
Wichita, Kansas, 67208
Kokomo, Indiana, 46904
Roanoke, Virginia, 24016
Chicago, Illinois, 60612
Macomb, Illinois, 61455
Atlanta, Georgia, 30342
Albuquerque, New Mexico, 87102
Tacoma, Washington, 98405
Green Bay, Wisconsin, 54311
Savannah, Georgia, 31405
Ann Arbor, Michigan, 48106
Prairie Village, Kansas, 66208
Grand Rapids, Michigan, 49503
Sioux City, Iowa, 51102
Lewiston, Idaho, 83501
Saint Joseph, Missouri, 64507
Detroit, Michigan, 48201
Englewood, Colorado, 80113
Worcester, Massachusetts, 01605
Ottawa, Illinois, 61350
Elkhart, Indiana, 46514-2098
Saint Joseph, Missouri, 64507
Neptune, New Jersey, 07753
Shawnee Mission, Kansas, 66204
West Reading, Pennsylvania, 19611
Sylvania, Ohio, 43560
Pueblo, Colorado, 81008
Des Moines, Iowa, 50309
Winston-Salem, North Carolina, 27104
Munster, Indiana, 46321
Saint Joseph, Michigan, 49085
Columbus, Ohio, 43215
Traverse City, Michigan, 49684
Overland Park, Kansas, 66209
Marinette, Wisconsin, 54143
Puyallup, Washington, 98372
Oregon, Ohio, 43616

Tracking Information

NCT #
NCT00954174
Collaborators
National Cancer Institute (NCI)
Investigators
  • Principal Investigator: Matthew A Powell NRG Oncology
  • Matthew A Powell NRG Oncology