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407 active trials for Quality of Life

Efficacy of a Self-advocacy Serious Game Intervention

Individuals with cancer must overcome multiple, ongoing challenges ("self-advocate") related to their cancer experience to receive patient-centered care. Women with metastatic breast or advanced gynecologic cancer often face significant challenges managing their quality of life concerns and cancer- and treatment-related symptoms. If they do not self-advocate to manage these concerns, they risk having poor quality of life, high symptom burden, and care that is not patient-centered. Serious games (video games that teach) are effective health interventions that allow users to vicariously engage in situations reflecting their personal experiences, receive meaningful information, and learn personally relevant skills that they can apply in real life. The goal of the current study is to test the efficacy of a novel intervention using a serious game platform to teach self-advocacy skills to women with metastatic breast or advanced gynecologic cancer. The Strong Together intervention consists of a multi-session, interactive serious game application with tailored self-advocacy goal-setting and training. The serious game is based on a self-advocacy conceptual framework and applies behavior change theories and serious game mechanisms to promote skill development and implementation. The game works by immersing users in the experiences of characters who are women with advanced cancer; requiring users to make decisions about how the characters self-advocate; demonstrating the positive and negative consequences of self-advocating or not, respectively; and providing multiple, individualized feedback mechanisms and game features to enforce self-advocacy skill acquisition and transference to real life.

Start: September 2021
The Effect of Aromatherapy Massage Applied to Hemodialysis Patients With Muscle Cramp

This study was planned as a randomized controlled and single-blind study consisting of qualitative and quantitative stages in order to evaluate the effect of aromatherapy massage on cramp frequency, cramp pain severity and quality of life in hemodialysis (HD) patients with cramps. The study will start with a total of 48 patients, including 16 patients in each group. The number of patients to be included in the groups will be determined by making an interim evaluation of the obtained data. In the study, aromatherapy massage was applied to the intervention group and baby oil massage was applied to the placebo group, while no application other than routine care would be applied to the control group. Research data; Intervention and Placebo Group Situation Assessment Chart, Personal Information Form, Personal Interview Form, Visual Analog Scala, Quality of Life Index Dialysis Version-III (Ferrans & Powers) and Control, Intervention and Placebo Group Monitoring Chart will be collected. Qualitative data obtained in the research will be evaluated using descriptive analysis and content analysis methods. Statistical Package for the Social Sciences (SPSS) program and Turcosa program (Turcosa Analytics Ltd Co, Turkey, www.turcosa.com.tr) are planned to be used in the evaluation of quantitative data. A value of p <0.05 will be considered as the criterion for statistical significance. In order to conduct the study, the necessary Academic Committee decision, Ethics Committee approval (date 11 November 2020 and number 13) and institutional permission were obtained. The individuals included in the study will be informed about the purpose of the research, their verbal consent will be obtained and the participant's informed consent form will be signed.

Start: November 2020
IVM Versus IVF: Differences in Patients' Emotional Adjustment and Quality of Life

Patients who undergo in vitro fertilization with or without intracytoplasmic sperm injection (IVF / ICSI) often experience an impact on their quality of life and emotional maladjustment to treatment and outcome. Multiple contributors to this negative impact have been identified, including interference with professional activities, expenses related to fertility treatment and hormonal side effects. In-vitro maturation (IVM) of human oocytes obtained from minimally stimulated or unstimulated ovaries offers a more "patient friendly" treatment option than the conventional ovarian stimulation protocols for Assisted Reproductive Technology (ART) treatment. Historically, IVM has been offered to women with increased ovarian response (so-called "high responders"), typically women with polycystic ovaries (PCO/PCOS), who are at increased risk for ovarian hyperstimulation syndrome (OHSS) if conventional ART protocols are used. IVM treatment programs are characterised by a minimal administration of fertility hormones, are less disruptive to patients' daily life through a reduced need for hormonal and ultrasound monitoring, avoid a range of minor and major complications because of the reduced hormonal burden of this procedure, and aim to reduce the total cost for of infertility treatment. To facilitate the application of IVM as a treatment that can potentially improve the overall patient experience, a study comparing the psychological impact of a conventional ovarian stimulation protocol versus an IVM protocol will be conducted; furthermore, a study investigating the differences in quality of life between the two subgroups will also be performed. Socio-demographic data, medical characteristics and the following questionnaires will be collected: Specific questions for patients with fertility problems (FertiQol); Hospital Anxiety and Depression Scale (HAD) and an instrument to measure side effects designed by the research group. The study group (IVF patients and IVM patients) will be evaluated at three predefined time points: at intake, after oocyte collection and when the outcome after the first embryo transfer is known. Descriptive analysis, intergroup comparisons and explanatory/predictive model of the dependent variables (quality of life, emotional adjustment) will be performed.

Start: August 2017