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18 active trials for Primary Hyperparathyroidism

Disorders of Bone and Mineral Metabolism

Background: Disorders of bone and mineral metabolism particularly parathyroid disorders like multiple endocrine neoplasia type 1, jaw tumor syndrome, familial hypocalciuric hypercalcemia, parathyroid cancer, osteoporosis, and Paget s disease. Advances have been made in the past few decades. But, there remains a significant gap in the knowledge about these disorders. Researchers want to collect information from people with these disorders to learn more. Objective: To create a collection of data and samples that researchers can use for studies of bone and mineral metabolism or other related diseases or conditions. Eligibility: People ages 6 months or older who have or are at risk of having a bone and mineral metabolism disorder. Design: Participants will be screened with a review of their medical records. Participants will be seen, tested, and treated by doctors based on their condition. Their visits may be in person or via telehealth. Participants will complete questionnaires. They will answer questions about their physical, mental, and social health. Participants may give samples such as saliva, blood, urine, or stool. Participants may give cheek cell samples. They will do this using a cheek swab or by spitting into a cup. Adult participants may give a skin biopsy. For this, a small bit of skin is removed with a punch tool. Participants may have medical photos taken. If participants have surgery during the course of their regular care either at the NIH or at a different hospital or doctor s office, researchers will ask for some of the leftover tissue. Participants will remain in the study indefinitely and may be followed longitudinally on a as needed basis.

Bethesda, MarylandStart: September 2021