ALND vs RDT in Positive Sentinel Node After Neoadjuvant Therapy
In the case of primary surgery, in patients with sentinel node involvement, it has already been shown that omitting axillary lymph node dissection (ALND), often combining axillary radiotherapy (RT), does not worsen the prognosis and does significantly reduce the appearance of lymphedema. However, patients who have received neoadjuvant systemic treatment cannot benefit from this option, even though in the majority of those who have responded well to treatment, a residual disease in the armpit is low, but there are no studies yet published that supports the possibility of not performing lymphadenectomy. The primary endpoint of this study is to assess whether the irradiation of the axilla concerning axillary lymph node dissection is not inferior in recurrences and overall survival, in patients with positive sentinel lymph node (SN) after neoadjuvant systemic treatment.
Start: June 2021
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