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355 active trials for Asthma

NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)

Background: - Asthma is a serious clinical and public health problem. Researchers want to collect data to better understand how bacteria and other things in the environment can affect people's asthma. Eligibility: - Nonsmoking adults age 18 - 60 who have moderate to severe asthma and are not pregnant or breastfeeding. Design: Partaicipants will complete a medical history form before the first visit. Study visits will include collecting medical history, and conducting physical exam, lung and smoking tests. Participants will give blood, urine, stool, dust, saliva, and sputum samples. Participants will take tests that measure their breathing abilities. They will give saliva samples for DNA study. They will get kits to collect stool and dust samples at home. They will fill out surveys. Participants will have visits every 6 months for 5 years. They can schedule sick visits, if needed, at no cost to the participant. For all visits, they will have asthma check-ups and get treatment, at no cost to the participant. Some participants may take part in a sub-study that includes one 4-hour visit. They will have medical history, physical exam, and lung tests. They will have urine tests to check for pregnancy and tobacco exposure. Then they will have bronchoscopy. For this, an intravenous line will be placed in an arm vein. The nose and throat will be numbed. A flexible fiber-optic tube will be inserted into their airways through the nose. Their airways will be examined and areas of their lung will be washed. A small sample of cells will be taken.

Start: September 2015
Longitudinal Observational Study of Severe Asthma

Background: - Asthma is a lung condition that causes difficulty breathing and decreased lung function. Some people with asthma have more severe disease symptoms. They may be less responsive to standard treatments such as steroids. Researchers want to compare severe asthmatics with mild or moderate asthmatics or people without asthma over a long period. This information may help identify new treatments for people whose asthma is not well controlled by standard medications. Objectives: - To compare severe asthmatics with mild or moderate asthmatics, and healthy volunteers, to study the progression and outcomes of the disease. Eligibility: Individuals at least 18 years of age who have been diagnosed with asthma for at least 1 year. Healthy volunteers at least 18 years of age. Design: This study will involve an initial visit to the NIH Clinical Center for all participants. Selected participants may be asked to return for repeat visits over a number of years. The test results from participants with asthma will be compared with those from the healthy volunteers. All participants will be screened with a physical exam and medical history. Participants may (but will not necessarily) have the following tests at each visit: Complete medical history and physical exam Blood, urine, sputum, and nasal cell samples Breath tests and heart and lung function tests Six-minute walk test to measure ability to exercise Imaging studies such as chest x-rays, bone density scans, and sinus scans Allergy skin testing Vocal cord exam Overnight sleep study Participants may remain on the study for as long as they are willing to participate and do not develop health problems that will interfere with the study.

Start: March 2013